水熱法合成氫氧基磷灰石之鈣磷比研究

Ca/P Ratio Influence for Hydroxyapatite Synthesis via Hydrothermal Method

吳玉祥(Yu-Shiang Wu) ； 黃建瑋(Jian-Wei Huang)

《中華科技大學學報》 45期 (2010/10) Pp. 1-14

https://doi.org/10.7095/JCUST.201010.0001

摘要

本研究係利用水熱法，將奈米碳酸鈣(CaCO3)和磷酸氫二銨((NH4)2HPO4)的水溶液在密閉壓力釜中產生反應，於高壓下轉變成超臨界流體，持溫一段時間使反應物粒子間能交互作用，形成適當的中間產物，在降溫過程中成長晶體而形成所需的結晶相，製備出奈米級氫氧基磷灰石(HAp)粉末，藉由控制不同的Ca/P莫耳比的起始原料，可得到成份與形態不同的氫氧基磷灰石。實驗結果發現，在250℃持溫8小時、溶液pH值為10、NaOH為礦化劑的製程參數，在Ca/P莫耳比為3:3的條件下，可以得到較佳的HAp結晶相，並呈現均勻規則的HAp針狀與棒狀晶體；隨著Ca/P莫耳比的升高，在5:3與6:3時會出現少數未反應完全之CaCO3與β-TCP。

關鍵字

水熱法 ； 壓力釡 ； 碳酸鈣 ； 氫氧基磷灰石

並列摘要

Hydrothermal method was used to make nano carbonate (CaCO3) and diammonium hydrogen phosphate ((NH4)2HPO4) solution to react with each other and form a supercritical fluid under high pressure in a closed autoclave. A certain temperature was maintained for a fixed time to allow the reactant particles to fully interact until an appropriate intermediate formed. To form nano hydroxyapatite (HAp) powder, the desired crystalline phase was obtained as the crystal took shape during the cooling process. Through the control of different Ca/P molar ratios, HAp of varied compositions and types could be derived. The results showed that purer HAp crystalline phase could be obtained when the following manufacturing parameters were used: temperature maintained at 250℃ for 8 hours, a pH value of 10 and NaOH as mineralizer. The derived HAp shows the regular needle and rod shape crystal. When Ca/P molar ratio was adjusted to be higher, which is 5:3 or 6:3, there would be a situation when CaCO3 failed to fully react and a few CaCO3 and β-TCP particles could be observed.

並列關鍵字

Hydrothermal method ； autoclave ； calcium carbonate ； hydroxyapatite