Can Immediate Debridement with Biobrane Dressing Decrease the Infection Rate and Length of Hospital Stay for Pediatric Burn Patients?

即時清創並給予Biobrane可以減少燒傷病童感染率和住院天數嗎？

楊正三(Cheng-San Yang) ； 郭浩然(How-Ran Guo)

《臺灣整形外科醫學會雜誌》 20卷1期 (2011/03) Pp. 31-36

https://doi.org/10.7096/TJTSPS.201103.0031

摘要

背景：
先前的研究顯示，Biobrane和抗菌Silvadene的效用存有爭議，亟待驗證。因此，我們進行了一項回顧性研究，評估早期使用Biobrane或使用具抗菌性Silvadene，何種敷料能更有效地減少感染率和住院天數。
目的及目標：
此研究之目的爲探討燒傷病童，比較Silvadene和Biobrane，對於傷口感染機率和住院天數長短的影響。
材料及方法：
我們回顧從2000年到2007年間，來本教學醫院之燒傷中心就診的68位燒傷病童，收集資料包括性別、年齡、住院天數、燒傷種類、治療方式、後續手術有無、傷口細菌培養。
結果：
Biobrane組(n=18)相較於Silvadene組(n=50)有較低的感染率(33% vs. 68%, p=0.013)，但在後續手術率(11% vs. 22%, p=0.488)和住院時間(13.2±5.0 vs. 14.1±5.4 days, p=0.917)，不具顯著性差異。傷口培養之細菌最常見爲Staphylococcus（30例），Enterococcus（12例），and Viridans streptococcus （7例）。
結論：
立即使用Biobrane，相較於抗菌性Silvadene，有較低的感染率，但在後續手術率和住院時間，不具顯著性差異。

並列摘要

Background:
Previous studies have shown that the therapeutic effects of Biobrane and antimicrobial Silvadene dressing are controversial and required to validate. Therefore, we conducted a retrospective study to evaluate whether the early application of Biobrane or Silvadene dressing is more effective in reducing infections and leading to satisfied outcomes for pediatric burn patients.
Aim and Objectives:
The aim of this study was to compare the effects of antimicrobial Silvadene and immediate Biobrane dressing on the infection rate of burn injuries and length of hospital stay for pediatric burn patients.
Materials and Methods:
We collected data on 68 pediatric burn injury patients who were admitted to the burn unit of a teaching hospital in Taiwan from 2000 to 2007. The data included gender, age, length of hospital stay, type of burn, type of treatment, subsequent operation, and wound culture of each patient.
Results:
The Biobrane group (n=18) had a lower overall infection rate than the Silvadene group (n=50) (33% vs. 68%, p=0.013), but the differences in the subsequent operation rate (11% vs. 22%, p=0.488) and length of hospital stay (13.2±5.0 vs. 14.1±5.4 days, p=0.917) were insignificant. The bacteria that were most frequently harvested from wound cultures were Staphylococcus (30 patients), Enterococcus (12 patients), and Viridans streptococcus (7 patients).
Conclusions:
Immediate Biobrane dressing can lead to a lower infection rate than Silvadene, but the differences in the subsequent operation rate and length of hospital stay were statistically insignificant.

並列關鍵字

immediate Biobrane dressing ； Silvadene ； infection rate ； length of hospital stay