Among all kinds of sport injuries of the knee joint, anterior cruciate ligament (ACL) is indeed the most prevalent kind. The incidence rate becomes even higher with more people engaged in sports activities. It is therefore required of the nursing staff in orthopedic departments to be equipped with a complete knowledge about procedures in the proper care of these patients with ACL injuries. This article aims at giving a systemic overview of the mechanism, symptoms and signs, diagnosis, treatment, nursing practice, and rehabilitation of ACL injuries. It is hoped that a better understanding of this type of injury will help nursing staff in better use of a systemic guidance, appropriate mental support and education while treating patients of this kind. In turn, these patients will gain higher self-control, better self-care, and faster recovery to normal everyday life. They will enjoy a better quality of life.