The ”Global Change” issues stress that the long-term regional environmental pollution and changes has affected the global climate, water; ecology and environment, through the atmospheric circulation, ocean circulation, water cycle and geochemical cycles. Furthermore, the expected future population growth and the energy-consumption growth is going to cause further deterioration of the global environment and an irreversible change of the global climate, unless the concept of sustainable development can be materialized in the future. Owing to the extended coverage of the global change issues, the inter-discipline interactions among many academic fields are very important to the understanding of the related subjects. This paper tries to explain the fundamental concepts and to introduce the Global Change Center of the National Taiwan University. Also, a course on Global Change arranged by NTU-GCC is being introduced.