新生兒硬皮症(Sclerema neonatorum)

Summary in English Neonatal Sclerema

陳烱霖(Chiung-Ling Chen) ； 錢光新(Kouang-Sing Ts'ien) ； 劉麗娜(Li-Na Liu)

《Acta Paediatrica Sinica》 1卷1期 (1960/03) Pp. 20-27

摘要

作者將1953年至1959年間於臺大醫院小兒科所觀察之20例作一報告。
此20例中17例不足1500公分，僅3例超2500公分（第1圖）。14例為男性，6例為女性。14例之營養物為牛乳，3例為母乳，3例死前尚未哺乳。臺灣寒冷季節患病之病例較多（第3圖）。
大部患孩之症狀乃於生後第2－3天開始，最多患病之部份為下肢，臀部及背部（第一表）。
17例曾用內泌素治療（第5表）。治療結果似顯示用cortisone及prednisolone等治療者較用ACTH治療者有較佳之效果：用cortisone及prednisolone等治療者9例中有6例痊癒，用ACTH治療者8例中僅1例痊癒。用prednisolone治療較cortisone，kenacort及ACTH有較快效果。
作者並簡論新生兒硬皮症之致病原因，臨床症狀，診斷、病理、預後及治療。

並列摘要

20 cases of neonatal sclerema observed during the period of 1953—1959 at the Pediatric Department of the National Taiwan University Hospital were reported.
17 cases weighed less than 2500gm. at birth, only 3 cases exceeded 2500gm. (Fig.1) 14 cases were males, 6 females. 14 cases were fed with cow milk exclusively, 3 cases were breast fed and 3 cases died before feeding with milk. The cases were found more frequently among the cold season than the other seasons in Taiwan. (Fig 3)
The onset of sclerema occurred in great majority at the second and third days of the 1ife. Lower extremities, buttocks and back (Table 1) were most frequently involved.
Hormone therapy was undertaken (Table 5) in 17 cases. The therapeutic results showed that cortisone and prednisolone yielded better results than ACTH: there were 6 survivals among 9 patients in the group treated with either cortisone or prednisolone in contrast to only 1 survival among 8 patients in the group treated with ACTH. Prednisolone was apparently superior to cortisone, kenacort or ACTH. for its more rapid effect.
The etiopathogenesis, clinical manifestations, diagnosis, pathology, prognosis and treatment of neonatal sclerema were briefly discussed.