- 期刊
Subcutaneous Fat Necrosis of Newborn: Report of Two Cases
新生兒皮下脂肪壞死：二病例報告
摘要
新生兒皮下脂肪壞死是一種少見的自癒性的脂肪炎，多見於足月但體重過重的巨嬰。其臨床的特徵是於背部、臀部與頰部等易受壓迫的部位，皮膚出現紫紅色或正常顏色的結節或皮下硬塊。病理上可見小葉性脂肪炎（lobular panniculitis），有脂肪壞死及具特徵的放射針狀隙縫(needle-shaped clefts)。我們報告2例臨床表現及病理變化較不尋常的病例。這兩名足月巨嬰同是經產道出生，於出生時都有生產創傷，他們分別是出生後第16天及第6天，意外地被發現頜下有無症狀性的結節，表面皮膚正常，結節分別於2個月及1個月大時自然消失。組織病理證實為新生兒皮下脂肪壞死，但其炎性浸潤中含多量的嗜伊紅性白血球。由於以往的文獻未有發生於頜下及有嗜伊紅性白血球浸潤的報告，我們特此提出報告並建議將此病列入新生兒頜下結節及富含嗜伊紅性白血球浸潤的小葉性脂肪炎的臨床及病理的鑑別診斷中。
關鍵字
無資料並列摘要
Subcutaneous fat necrosis of newborn (SFNN) is an uncommon disorder. Submandibular lesion and tissue eosinophilia have not been documented. Two patients with unusual location and unusual pathological findings are reported. Both patients were giant babies, delivered by vaginal route spontaneously with birth injury. Asymptomatic subcutaneous nodules were found over the submandibular area at the ages of 16 and 6 days respectively. Nodules disappeared spontaneously at the age of one month in the first, and two months in the second patient. Histopathological examination of the nodules revealed features typical for SFNN: lobular panniculitis with fat necrosis and radiating needle-shaped clefts within multinucleated histiocytes. In addition to mononuclear cells, eosinophils were abundant in the inflitrate. Because of these unusual features, it is suggested that SFNN should be considered in the differential diagnosis of submandibular subcutaneous nodule in the newborn, clinically; and of lobular panniculitis with eosinophilia, histologically.