Serum HDL Level at Acute Stage of Kawasaki Disease

川崎氏證是一種原因未明的血管發炎疾病,為了研究血中高密度脂蛋白(HDL)的變化是否能做早期診斷川崎氏症(KD)的特異性血清標誌,我們找了三組病人,于住院當天和一周後,分別抽血測血脂肪(包含HDL，LDL，TC，TG)的濃度，這三組病人有56位川崎氏症患者、38位元病毒感染患者、42位元細菌感染患者。結果顯示，於住院當天，三組病人皆有高度密度脂蛋白降低和三酸甘油脂增加的現象，並且，于一周後，沒有顯著恢復正常的跡象。病症程度較嚴重的病人，高密度脂蛋白降得較低。由於各種急性感染皆有變化就無法做為早期診斷川崎氏症的特展性血清標誌。本研究中，一個值得注意的發現是所有發燒病人都有某種程度的高密度脂蛋白降低。至於這種血脂肪變化的詳細機轉和長遠影響，需進一步研究加以證實。

關鍵字

高密度脂蛋白；川崎氏症；病毒感染；細菌感染

並列摘要

Kawasaki disease is a disease of acute vascular inflammation of unknown etiology and HDL is a known risk factor of vascular damage. So far, there is no specific serum marker for KD. The previous study has shown a remarkable change of serum HDL in the patients with KD. To find whether changes in serum HDL level is a specific serum marker for early diagnosis of KD, we measured the concentration of HDL, LDL, TC, TG and CRP immediately after admission and one week later in three groups of patients (56 patients with KD, 38 patients with clinical viral infection, and 42 patients with bacterial infection). There was a significant decrease of HDL and increase of TG immediately after admission in three groups of patients. HDL and TG did not return to normal one week later. HDL level is more adversely affected in severe diseases than in mild diseases. Our results indicated that low HDL level is noted in various acute infection and is not a specific serum marker in the early stage of Kawasaki disease. it is interesting that low HDL is a universal phenomenon in this series. Further research is needed to explain the mechanism of lipid alterations and its consequences.

並列關鍵字

high density lipoprotein ； Kawasaki disease ； viral infection ； bacterial infection

國際替代計量

Serum HDL Level at Acute Stage of Kawasaki Disease

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