Background & Problems: The unit promoted the use of a disease management information system, but lacked consensus regarding its use. The problems that were identified included: the business-oriented design of the information system, lack of education and training, dual-track operations, and awkward operation interface. Use of the information system among nurses in the unit had thus decreased over time. Purpose: To increase the prevalence of use of the disease management information system. Resolution: The diffusion of innovation theory was applied to strengthen the innovative characteristics of the disease management information system. The improvement measures adopted included: incorporation of recommendations, revision of the information system, provision of testing, arranging education and training sessions for the nurses, implementation of a regular audit system, and the revision of standard operating procedures. Result: The prevalence of use of the disease management information system increased from 33.3% pretest to 100% posttest. Conclusions: This project applied the diffusion of innovation theory to strengthen the innovative characteristics of the disease management information system, guide the nurses to adapt and change, and improve their use of and satisfaction with the disease management information system.