Xiu-yuan Chen was a famous physician in Qing dynasty. The thought of Nuke-yao-zhi wrote by Chen's, menstrual disease was determined treatment from spleen-gastric theory which appreciated identify pattern of vacuity and repletion with yin and yang overcome each other. He though that woman's infertility was related to constitution if her menstrual cycle normality with healthy body. He treated ante-and post-partum diseases almost according principles of Jin-qui-yao-lue wrote by Zhang zhong-jing. The character of Nu-ke-yao-zhi, Chen's invented one prescription of regulatory menstruation about yin and yang overcome each other, which's named Si wu tang added cyperus, root poria and licorice. And he created a protected fetal decoction in pregnancy named Suo yi zai wan. The decoction broadly applied to treat habitual abortion by physician in clinic.