Diabetic Dogs with Concurrent Hyperadrenocorticism: A Retrospective Study of 11 Cases during 1995-1999

糖尿病犬隻併發腎上腺皮質功能亢進症：1995年至1999年間11病例之回溯性研究

黃慧璧(Hui-Pi Huang) ； 連于欣(Yu-Hsin Lien) ； 張本恆(Peng-Heng Chang)

《中華民國獸醫學會雜誌》 26卷2期 (2000/06) Pp. 96-102

https://doi.org/10.7009/JTCSVS.200006.0096

摘要

腎上腺皮質功能亢進症具有結抗胰島素的作用，干擾胰島素治療，是造成抗胰島素治療失效的常見原因。本研究共收集併發腎上腺皮質功能亢進症之11例控制不良糖尿病犬隻（平均年齡9.4±3.2歲）進行研究，其中9例為雌性。主要的臨床呈象包括：嗜食（11/11）、頻渴（10/11）、多尿（10/11）、皮毛病變（9/11）胃腸道不通（9/11）、雙側性白內障（8/11）與消瘦（8/11）。持續性禁食後高血糖症（11/11）、尿糖（11/11）、ALKP升高（10/11）、低血納症（10/11）、高血脂症（9/11）、低血氯症（9/11）、酮尿（8/11）是此11例常見的檢驗異常。由腎上腺皮質激素刺激檢驗結果與醫學影像的檢查發現：此11例腎上腺皮質功能亢進症中6例是腦下垂體型、1例為腎上腺腫瘤、4例為醫源性。7例自發型的腎上腺皮質功能亢進症的犬隻中，4例（4/7）在腎上腺皮質功能亢進症的治療下，其糖尿病獲得良好的控制；3例因醫源性造成的腎上腺皮質功能亢進症犬隻，也在醫源性腎上腺皮質功能亢進症恢復後，其糖尿病獲得良好的控制。

關鍵字

糖尿病 ； 腎上腺皮質功能亢進症 ； 犬

並列摘要

Hyperadrenocorticism (HAC) is insulin antagonistic that can interfere with insulin therapy. It is a common cause of insulin resistance in diabetic dogs. Eleven poorly regulated diabetic dogs (mean age: 9.4±3.2 years) with concurrent HAC were studied. Nine of them (9/11) were females. Predominant clinical findings included: polyphagia (11/11). polydipsia (10/11), polyuria (10/11), cutaneous manifestations (9/11), gastrointestinal upsets (9/11), bilateral cataracts (8/11) and weight loss (8/11). Persistent fasting hyperglycemia (11/11), glycosuria (11/11), elevated ALKP (10/11), hyponatremia (10/11), lipemia (9/11), hypochloremia (9/11) and ketonuria (8/11) were the most consistent findings in laboratory tests. 8ased on results of adrenocorticotropic hormone stimulation tests and medical images, 6 were pituitary-dependent HAC, 1 had adrenal tumor, 4 were iatrogenic HAC. In 7 dogs with spontaneous HAC, 4 had good diabetic regulation after HAC was managed. Three dogs with iatrogenic HAC also showed good diabetic regulation after remiss ion of iatrogenic HAC was completed.

並列關鍵字

Diabetes mellitus ； Hyperadrenocorticism ； Canine