Prevention of Hypotension after Spinal Anesthesia for Cesarean Section: Dextran 40 versus Lactated Ringer's Solution

産婦接受脊髓麻醉導致低血壓之預防：比較Dextran 40與Lactated Ringer's溶液

林朝順(Chao-Shun Lin) ； 林子玉(Tzu-Yu Lin) ； 黃啟祥(Chi-Hsiang Huang) ； 林鈺樺(Yu-Hua Lin) ； 林中仁(Chung-Ren Lin) ； 詹偉弘(Wei-Hung Chan) ； 蔡勝國(Shen-Kou Tsai)

《Acta Anaesthesiologica Sinica》 37卷2期 (1999/06) Pp. 55-59

https://doi.org/10.6955/AAS.199906.0055

摘要

Background: This study was designed to compare the efficacy of 10% dextran 40 with lactated Ringer’s (LR) solution in reducing the incidence and severity of hypotension after spinal anesthesia for Cesarean section.
Methods: Sixty ASA grade I patients scheduled for Cesarean section were randomized into two groups in a double-blind fashion to receive either 500 ml of dextran 40 or 1000 ml of LR solution prior to induction of spinal anesthesia.
Results: The incidence of hypotension was 16 in 30 (53.3%) in the LR solution group and 8 in 30 (26.7%) in the dextran group (P＜0.05). The required dose of ephedrine for treatment of hypotension was significantly greater in the LR solution group than in the dextran group (15.5 mg versus 3.2 mg, P＜0.05). Neonatal outcome, as determined by Apgar score, was good and similar in both groups.
Conclusions: We concluded that 500 ml of dextran 40 is more effective than 1000 ml of lactated Ringer’s solution in reducing the incidence of hypotension induced by spinal anesthesia.

關鍵字

脊髓麻醉 ； 低血壓 ； 剖腹生產 ； Dextrans

並列摘要

Background: This study was designed to compare the efficacy of 10% dextran 40 with lactated Ringer’s (LR) solution in reducing the incidence and severity of hypotension after spinal anesthesia for Cesarean section.
Methods: Sixty ASA grade I patients scheduled for Cesarean section were randomized into two groups in a double-blind fashion to receive either 500 ml of dextran 40 or 1000 ml of LR solution prior to induction of spinal anesthesia.
Results: The incidence of hypotension was 16 in 30 (53.3%) in the LR solution group and 8 in 30 (26.7%) in the dextran group (P＜0.05). The required dose of ephedrine for treatment of hypotension was significantly greater in the LR solution group than in the dextran group (15.5 mg versus 3.2 mg, P＜0.05). Neonatal outcome, as determined by Apgar score, was good and similar in both groups.
Conclusions: We concluded that 500 ml of dextran 40 is more effective than 1000 ml of lactated Ringer’s solution in reducing the incidence of hypotension induced by spinal anesthesia.

並列關鍵字

Anesthesia,spinal ； Hypotension ； Delivery,Cesarean section ； Dextrans