Propofol-Sodium Thiopental Admixture Reduces Pain on Injection

Propofol與Sodium thiopental混合可減輕Propofol注射時的疼痛

高宜娟(Yi-Chuan Kau) ； 吳世銓(Rick Sai-Chuen Wu) ； 鄭嘉遜(Ka-Shun Cheng)

《Acta Anaesthesiologica Sinica》 38卷1期 (2000/03) Pp. 9-13

https://doi.org/10.6955/AAS.200003.0009

摘要

背景：Propofol在注射時常導致疼痛。近來曾有報告指出propofol與sodium thiopental混合注射用於節省成本並能減少疼痛。
方法：利用隨機雙盲實驗來比較不同比例的propofol與sodium thiopental混合劑注射進産生疼痛的程度。將146位ASA classⅠ的病人分成7組（純propofol、純sodium thiopental、propofol分別混以10%、20%、30%、40%和50%容積比例之sodium thiopental溶液），根據病人在注射藥物時的反應分成很痛、中度痛、輕微痛、和不痛四種程度記錄。
結果：純propofol注射時産生的疼痛遠超過其他6組配方。但改變sodium thiopental的比例對於疼痛的改善並無差異。
結論：sodium thiopental和propofol混合即可減輕注射時疼痛。即使只加10%容積的sodium thiopental仍有減少propofol注射時疼痛的效果。

關鍵字

靜脈麻醉劑：sodium thiopental, propofol ； 疼痛 ； 靜脈注射

並列摘要

Background: Propofol injection associated with a high incidence of pain is well known. Propofol and sodium thiopental mixture has recently been reported to be used for cost saving and able to reduce pain on injection.
Methods: This prospective, randomized, double blind trial was designed to compare the efficacy of different percentages of propofol and sodium thiopental mixture in minimizing propofol injection pain. 146 ASA class 1 patients were assigned to seven groups (pure propofol, pure sodium thiopental, and propofol premixed with 10%, 20%, 30%, 40%, and 50% of sodium thiopental). The instensity of pain was graded and recorded as severe, moderate, mild and no pain according to the response of the patients to the injection.
Results: The intensity of injection pain was significantly greater for pure propofol than the others while it was not significantly different among the other groups in comparison.
Conclusions: Sodium thiopental, when added to propofol, can significantly reduce propofol injection pain. This attenuation effect was noted even with as low as 10 volume % of sodium thiopental.

並列關鍵字

Anesthetics, intravenous: sodium thiopental, propofol ； Pain ； Injection, intravenous