This article explores a young man who suffered from cardiac thrombosis leading to stroke complicated by aphasia and motor deficits. This resuited in a chronic care process loading to depressed mood, hopelessness and depression in the young man. The nursing care comprised the application of Watson's theory, through observation, interview, empathy and care to establish a good nurse-patient relationship, a comprehensive evaluation of the collection of health problems, the case of ”physical activity dysfunction,” and ”high risk of injury/falls,” ”hopelessness,” and ”the part of a specific disease-related knowledge deficit.” This nursing process used care and unique feature, the key to effective control of rehabilitation, according to individual needs rehabilitation activities arranged to guide the important cognitive rehabilitation through the ongoing care, to encourage expression of feelings, seeking family support, to reduce pain and trauma of heart, improve self-care ability, to regain confidence and develop positive coping skills. We hope to share the nursing experience, nursing personnel care as useful reference.