The purpose of this cross-sectional study was to evaluate the relationship of periodontal disease (PD) and cardiovascular disease (CVD). Participants comprised of 297 adults aged above 35 years from Taipei County. The data were analyzed by SAS JMP to determine the relationship between oral disease and chronic systemic disease. The results showed that the prevalence rate of PD was 69%. Severe community periodontal index (CPI) was found among older people and those with a lower education. The remaining number of teeth was also found to be lesser. Attachment loss also increased with age. Oral health related factors included gender, older age, low education, risk of cardiovascular disease, and betel quid chewing. The high risk group should carry out regular oral examination to enhance oral health and behavior.