Cardiovascular Responses of Rats to Electrical Stimulation of the Fastigial Nucleus and Local Microinjection of Amino Acids

頂核電刺激及氨基酸微量注射之心臟血管反應

黃廷飛(T. F. Huang) ； 彭英毅(Y. I. Peng) ； 謝正勇(J. Y. Shieh)

《The Chinese Journal of Physiology》 32卷1期 (1989/06) Pp. 31-39

摘要

頂核與心臟血管管制有關，但其機制尙未明白。本實驗用麻醉老鼠，檢討頂核電刺激及氨基酸L-glutamate，Kainic acid，glycine及GABA微量注射於頂核引起的心臟血管反應。其結果顯示頂核電刺激引起血壓上升或下降，心跳減低或不變，L-glutamate，Kainic acid 10-20μg注射於頂核，血壓上升或下降，心跳變慢，但glycine或GABA 10-20μg注射對血壓心跳無顯影響。L-glutamate，Kaimic acid及CaCl2微量注射注於頂核對EPinephrine靜脈注射引起的血壓上升反應無顯著影響，但減小心跳減慢反應。根據結果認為頂核與心臟血管管制有密接關係，而L-glutamate微量注射於頂核，對心臟血管機能有變調作用。

並列摘要

Huang,T.F.,Y.I.Peng and J.Y.Shieh: Cardiovascular responses of rats to electrical stimulation of the fastigial nucleus and local microinjection of amino acids. Chinese J.Physiol.32(1):31-39,1989.The cardiovascular response to electrical stimulation of the fastigial nucleus (FN) and microinjection of L-glutamate, kainic acid, glycine and GABA into the FN of anesthetized rats were studied. Electrical stimulation of FN produced pressor or depressor responses with a decrease or no change in heart rate depending upon the intensity or site of the stimulation. Microinjection of L-glutamate or kainic acid into the FN elicited pressor or depressor response with bradycardia, while that of glycine or GABA did not affect blood pressure or heart rate. L-glutamate or kainic acid microinjected into the FN did not affect epinephrine-induced pressor response, but attenuated the bradycardic response. These results indicate that L-glutamate in the FN may play a role in modulation of the cardiovascular regulation.

並列關鍵字

fastigial nucleus ； electrical stimulation ； microinjection ； amino acids