Effect of Mannitol, N-2-Mercaptopropionyl Glycine and Sodium Nitroprusside on EEG Recovery Following Cerebral Ischemia and Reperfusion in the Rat

木蜜醇(mannitol)，硫丙甘氨酸(n-2-mercaptopropionyl glycine)，及硝基氬氰酸鈉(sodium nitroprusside)對老鼠腦缺血再灌流時腦電圖回復之效果

黃廷飛(Ting-Fei Huang) ； 黃莉玲(Li-Lin Huang)

《The Chinese Journal of Physiology》 33卷2期 (1990/06) Pp. 121-129

摘要

腦缺血及中風引起腦機能損害而帶來嚴重後果，其預防及治療頗爲重要。但在國內其實驗研究尙待加强。本實驗採用老鼠腦缺血及再灌流之實驗模型檢討游離根清除劑及血管擴大劑對腦缺血及再灌流後腦電圖回復之效果。
將麻醉老鼠結紮腦部四條動脈（椎骨動脈及頸動脈）而產生腦缺血30分鐘後再灌流腦部三小時，將藥物分別在腦缺血前及再灌流後靜脈注射各一次。在實驗各期觀察腦電圖，血壓及心跳之變化。其結果顯示，游離根清除劑mannitol 20～50 mg/kg，n-2-mercaptopropionyl glycine 10～20 mg/kg及血管擴張劑sodium nitroprusside 20～50 μg/kg單獨或合併投與，顯著改善腦電圖之回復。

並列摘要

The efficacy of free radical scavengers (mannitol and n-2-mercaptopropionyl glycine) and a vasodilator (sodium nitroprusside) on the EEG recovery following cerebral ischemia was studied in the anesthetized rat. Global ischemia of brain was produced by the four-vessel occlusion for 30 min followed by 3h reperfusion. Blood pressure, heart rate and EEG were monitored. The test agents were infused intravenously 15 min before and immediately after cerebral ischemia. The results indicate that mannitol 20-50 mg/kg, n-2-mercaptopropionyl glycine 10-20 mg/kg and sodium nitroprusside 20-50 μg/kg singly or in combination improved EEG recovery during reperfusion.

並列關鍵字

four-vessel occlusion ； reperfusion ； mannitol ； n-2-mercaptopropionyl glycine ； sodium nitroprusside