Bethanechol Induced Contraction in Mouse Spleen

Bethanechol導致小白鼠脾臟收縮之探討

黃啓剛(K. K. Wong)

《The Chinese Journal of Physiology》 33卷2期 (1990/06) Pp. 161-167

摘要

Bethanechol被證實可導致小白鼠脾臟收縮。本文探討Bethanechol是否刺激毒蕈鹼樣接受體而直接引發離體脾臟收縮。研究結果顯示，Bethanechol可繼續增加phenylephrine導致的最大收縮，這表示Bethanechol所引發的收縮可能與刺激腎上腺素接受體無大關連；況且，Clonidine雖然可抑制Phenylephrine所導致的收縮，但並不能抑制Bethanechol所引發的收縮，而這結論並未與以上構想相反。這些結果提示，Bethanechol所導致的脾臟收縮可能經直接刺激毒蕈鹼樣接受體而產生，並對Bethanechol可能間接刺激交感神經、增加神經介質分泌而導致脾臟收縮的理論，似乎並不可能。

並列摘要

Bethanechol was shown to induce contraction in mouse spleen. The possibility of initiating such response by stimulating solely muscarinic receptors was tested in isolated spleens from mice. The present data showed that bethanechol was able to further increase the maximum splenic contraction induced by phenylephrine, suggesting that the bethanechol induced contraction was possibly unrelated to stimulating adrenergic receptors. Moreover, clonidine which was able to suppress the phenylephrine induced splenic contraction, was unable to suppress the splenic contraction induced by bethanechol, and this result supported the above notion. These data suggest that the bethanechol induced splenic contraction could be the result of a direct stimulation of muscarinic receptors in mouse spleens, and an indirect effect mediated through the stimulation by bethanechol of sympathetic neurotransmitter release from sympathetic varicosities seems unlikely.

並列關鍵字

Bethanechol ； phenylephrine ； clonidine ； muscarinic receptors ； splenic contraction