Profound Urinary Protein Loss and Acute Renal Failure Caused by Cyclooxygenase-2 Inhibitor

Yu-Hsin Chen ； Der-Cherng Tarng

《The Chinese Journal of Physiology》 54卷4期 (2011/08) Pp. 264-268

https://doi.org/10.4077/CJP.2011.AMM062

並列摘要

Cumulative evidence has shown that nonsteroidal anti-inflammatory drugs (NSAIDs) can induce acute renal failure and nephrotic-range proteinuria. Cyclooxygenase-2 (COX-2) inhibitors have less nephrotoxicity; however, recent data indicate that they may cause the same renal problems as NSAIDs do. Herein, we present a case of celecoxib-associated minimal change disease (MCD) with profound urinary protein loss and acute renal failure. Renal function and nephrotic syndrome in this patient resolved completely after discontinuation of celecoxib and treatment with methylprednisolone. Clinicians should keep high index of suspicions in patients developing nephrotic syndrome and acute renal failure after taking COX-2 inhibitors since secondary MCD responds well to timely cessation of COX-2 inhibitors and administration of steroid therapy.

並列關鍵字

acute renal failure ； cyclooxygenase-2 COX-2 inhibitors ； minimal change disease

參考文獻

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