Solvent Exposure, Alcohol Consumption and Liver Injury in Workers Manufacturing Paint

David Rees ； Neil Soderlund ； Roelof Cronje ； Ernest Song ； Danuta Kielkowski ； Jonathan Myers

《Scandinavian Journal of Work, Environment & Health》 19卷4期 (1993/07) Pp. 236-244

並列摘要

Liver enzyme activity was examined in 89 South African paint makers currently exposed to a mixture of organic solvents at fairly low levels. However, the duration of exposure was substantial for many. Fifty-eight workers (65%) had at least one enzyme value above the upper reference limit. Gamma glutamyl transferase (γGT) activity was elevated in 46% of the workers and aspartate aminotransferase (ASAT) in 52%. In a comparison between workers with high and low solvent exposure, the γGT and ASAT values were higher in the most exposed group (eg, γGT mean 108 versus 69 U•l^(-1), P＞0.05). Adjustment for confounding by alcohol consumption and body mass index eliminated the differences due to exposure. It was concluded that the measures of liver injury used did not demonstrate solvent-induced hepatic damage but that excessive alcohol consumption was an important factor.

並列關鍵字

alcohol ； hepatotoxicity ； liver enzymes ； paint manufacture ； organic solvent mixtures ； South Africa