Functions and Regulation of Insulin-like Growth Factors (IGFs) in Fish

魚類之類胰島素生長因子之功能與調控

吳金洌(Jen-Leih Wu) ； 郭欽明(Ching-Ming Kuo) ； 陳志毅(Jyh-Yih Chen)

《臺灣水產學會刊》 33卷3期 (2006/09) Pp. 193-208

https://doi.org/10.29822/JFST.200609.0001

摘要

相信日漸增多的人口會越來越依賴從水產養殖上所獲得之蛋白質飲食。類胰島素生長因子為生長激素荷爾蒙中之一員，與成長激素一起在魚類的成長、分化、代謝、銀化、性成熟及排卵過程中扮演要角，這些類胰島素生長因子系統中的配體、分子結構及調控類胰島素生長因子的限制因子皆詳述於本文中。前人研究證實類胰島素生長因子第一型及第二型在上述之功能中皆參與其中；然而，它們的表現與類胰島素生長因子結合蛋白及類胰島素生長因子受器之間的作用模式，取決於發育時期、性別、生理狀態、營養的利用、環境條件及濃度。類胰島素生長因子第一型及第二型在整個發育時期（包含未受精卵）及成年個體皆有表現。類胰島素生長因子第一型及第二型雖普遍表現在整個發育時期中所有的部位，然而肝臟才為其主要之表現器官，前者主要表現於肝臟，而後者主要表現於肝臟以外的地方。除此之外，還有許多重要的深入研究來討論其多樣的領域。

關鍵字

生長因子 ； 類胰島素生長因子 ； 類胰島素生長因子結合蛋白 ； 肝臟

並列摘要

It is believed that the burgeoning human demand for a proteinaceous diet can be capitulate from aquaculture. Insulin-like growth factors (IGFs) are a group of somatotropic hormones play pivotal role in fish integrated with GH for growth, differentiation, metabolism, smoltification, sexual maturation and spawning. The ligands of IGF system, molecular structure, limiting factors modulate IGFs actions in fish are described in this review. Accumulated in vivo and in vitro studies proved that IGF-Ⅰ and IGF-Ⅱ are involved in all the above functions, nevertheless, their expression, mode of action and amalgamation with IGFBPs, IGF-receptors was varied based on their developmental stage, sex, physiological status, nutrition availability, environmental condition and concentration. IGF-Ⅰ and IGF-Ⅱ expression were noticed in all developmental states (including unfertilized egg) and adult. During developmental the expression was noticed universally in all sites, however after differentiation liver plays pivotal role than other organs, between IGF-Ⅰ and IGF-Ⅱ expression, the leader secrete more in liver and the ultimate secreted more in extrahepatic tissues with certain exceptions. In addition, the importances of detailed study in various deficient areas are discussed.