Vasodilator Agents Inhibit Opossum Kidney Proximal Tubular Cell Growth

血管舒張劑抑負鼠近端賢小管細胞增生

朱宗信(Tzong-Shinn Chu) ； 吳明修(Ming-Shiou Wu) ； 謝博生(Bor-Shen Hsieh)

《Journal of the Formosan Medical Association》 104卷5期 (2005/05) Pp. 374-377

https://doi.org/10.29828/JFMA.200505.0013

並列摘要

Renal tubule cell hyperplasia and hypertrophy have been regarded as antecedents of tubulointerstitial fibrosis. Dipyridamole and pentoxifylline inhibit rat glomerular mesangial cell growth. The purpose of this study was to examine the effects of pentoxifylline and other vasodilators on opossum kidney proximal tubular (OKP) cell growth. A modified 3-(4, 5-dimethylthiazil-2-yl)-2, 5-diphenyltetrazolium bromide assay was used to evaluate cell proliferation in OKP cells. Pentoxifylline caused a dose-dependent inhibition of serum-stimulated proliferation of OKP cells: inhibition was 17%, 25%, and 37% at 0.03 mg/mL, 0.1 mg/mL, and 0.3 mg/mL, respectively. Dipyridamole 1.7 mg/L and 6 mg/L resulted in 34% and 46% inhibition, respectively. Verapamil 10^(-6) M, 10^(-5) M, and 10^(-4) M resulted in 34%, 46%, and 67% inhibitory, respectively. These inhibitory effects may contribute to renal protection or retardation of renal disease progression.

並列關鍵字

Cell proliferation ； Dipyridamole ； Kidney tubules ； proximal ； Pentoxifylline ； Verapamil