- 期刊
Milk Fortified with the Current Adequate Intake for Vitamin D (5μg) Increases Serum 25-Hydroxyvitamin D Compared to Control Milk but Is Not Sufficient to Prevent a Seasonal Decline in Young Women
維生素D（5 μg）強化的牛奶提高了血清25-羥維生素D水平但不足以預防年輕女性維生素D水平的季節性下降
摘要
Low vitamin D status in women of childbearing age may have implications for health. Vitamin D status of New Zealanders (NZ), based on low serum 25-hydroxyvitamin D (25OHD) is suboptimal. Vitamin D status may be improved with supplements and/or fortified foods. Recently an Adequate Intake (AI) for Australia and NZ was set at 5 μg/d vitamin D. We aimed to determine the effect of daily consumption of milk powder fortified with 5 μg vitamin D3 on serum 25OHD concentration over 12 wks. 73 non-pregnant women (18 - 47 y) living in Dunedin, NZ (46°S) were randomised to receive either unfortified (control) or fortified (5 μg vitamin D3) milk for 12 wks from January to April. Mean 25OHD was similar between groups at week 0 (control 74 vs 76 nmol/L) and fell significantly in both groups over the 12 weeks (control 53 nmol/L, fortified 65 nmol/L; p ＜ 0.001). After 12 wks the fortified milk group had a serum 25OHD 19% (95% CI; 7, 32%) higher (10 nmol/L) than the control group after adjusting for baseline levels (p ＜ 0.001). Daily consumption of fortified milk providing the current AI of 5 μg per day vitamin D3 for 12 weeks resulted in higher 25OHD concentrations than control milk. This dose was not sufficient to prevent the seasonal decline in 25OHD. This study suggests an AI of 5 μg may be inadequate for New Zealanders to allow for seasonal changes in sunlight exposure, and is unlikely sufficient for other populations with low sunlight exposure.
並列摘要
Low vitamin D status in women of childbearing age may have implications for health. Vitamin D status of New Zealanders (NZ), based on low serum 25-hydroxyvitamin D (25OHD) is suboptimal. Vitamin D status may be improved with supplements and/or fortified foods. Recently an Adequate Intake (AI) for Australia and NZ was set at 5 μg/d vitamin D. We aimed to determine the effect of daily consumption of milk powder fortified with 5 μg vitamin D3 on serum 25OHD concentration over 12 wks. 73 non-pregnant women (18 - 47 y) living in Dunedin, NZ (46°S) were randomised to receive either unfortified (control) or fortified (5 μg vitamin D3) milk for 12 wks from January to April. Mean 25OHD was similar between groups at week 0 (control 74 vs 76 nmol/L) and fell significantly in both groups over the 12 weeks (control 53 nmol/L, fortified 65 nmol/L; p ＜ 0.001). After 12 wks the fortified milk group had a serum 25OHD 19% (95% CI; 7, 32%) higher (10 nmol/L) than the control group after adjusting for baseline levels (p ＜ 0.001). Daily consumption of fortified milk providing the current AI of 5 μg per day vitamin D3 for 12 weeks resulted in higher 25OHD concentrations than control milk. This dose was not sufficient to prevent the seasonal decline in 25OHD. This study suggests an AI of 5 μg may be inadequate for New Zealanders to allow for seasonal changes in sunlight exposure, and is unlikely sufficient for other populations with low sunlight exposure.
延伸閱讀
- 吳白玟、方銘志、蕭惠文、董靜馨、蔡佳芬、戴偉倫、許雅鈞、潘志寬、鍾月容、施養志（2008）。嬰兒配方食品及較大嬰兒配方輔助食品中維生素B2、維生素B12、鈣及磷含量標示符合性評估。藥物食品檢驗局調查研究年報，()，207-211。https://doi.org/10.6946/ASRNL.200812.0207
- 沈蓓婷（2016）。母乳維生素A和D含量與嬰兒異位性皮膚炎關聯性之探討〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU201602208
- 蕭慧美、黃玟綺（2008）。維生素A補充飼料對大鼠肝臟細胞色素酵素P450 3A蛋白質的影響。嘉南學報（科技類），(34)，9-15。https://doi.org/10.29540/CNABST.200812.0002
- 張俊達、蕭宗法、楊德威、歐修汶、林義福、李春芳、王思涵（2016）。飼糧中補充維生素E與硒對熱季期間荷蘭泌乳牛泌乳性能與血液性狀之影響。台灣農學會報，17(3)，318-329。https://doi.org/10.6730/JAAT.201609_17(3).0006
- 張俊達、蕭宗法、楊德威、歐修汶、林義福、李春芳、蔡銘洋、王思涵（2017）。飼糧中補充維生素C與鐵對熱季期間荷蘭泌乳牛泌乳性能與血液性狀之影響。台灣農學會報，18(2)，97-111。https://doi.org/10.6730/JAAT.201706_18(2).0001