Relation of Plasma Somatostatin Levels with Malondialdehyde in Hyperlipidemic Patients

高脂血症患者血浆生长抑素水平与氧化应激的关系

Rui-Li Yang ； Wu Li ； Peng Yue ； Yong-Hui Shi ； Guo-Wei Le

《Asia Pacific Journal of Clinical Nutrition》 20卷2期 (2011/06) Pp. 220-224

https://doi.org/10.6133/apjcn.2011.20.2.12

摘要

生长抑素具有抑制胰腺内外分泌和胃肠消化吸收的功能，可能对机体高能摄入导致的胰岛素阻抗和氧化应激具有保护作用。许多研究也表明糖尿病和肥胖个体的生长抑素分泌紊乱。本研究目的是调查高脂血症患者的血浆生长抑素水平是否低于正常个体，并进而分析血浆生长抑素水平与动脉粥样硬化指数与MDA的关系。结果表明：高脂血症患者存在明显的氧化应激和胰岛素阻抗现象。高脂血症患者血浆生长抑素水平显著低于正常对照组，而且生长抑素水平与动脉粥样硬化指数和MDA水平呈显著负相关。這些數據说明，生长抑素分泌水平降低，可能与长期高能量摄入和体能活动不足攸关的高脂血症和动脉粥样硬化的发生密切相关。

關鍵字

生长抑素 ； 胰岛素阻抗 ； 氧化应激 ； MDA ； 高脂血症

並列摘要

Somatostatin (SST) may protect organism from overnutrition-induced insulin resistance and oxidative stress by inhibiting pancreatic endocrine and exocrine secretion, gastrointestinal digestion and absorption. Many studies clearly show its release becomes perturbed in diabetes and obesity. Therefore, in the present study we first aimed to investigate whether or not plasma somatostatin level was different in patients with hyperlipidemia and normolipidemic controls. We also assessed the relationship between plasma somatostatin levels with atherosclerotic index (AI) and malondialdehyde (MDA) in non-diabetic dyslipidemic patients. Subjects with hyperlipidemia have insulin resistance and high levels of oxidative stress. Median somatostatin (57.2±19.2 vs 68.0±21.9 pg/mL; p＜0.05) levels were lower in hyperlipidemic than in normolipidemic subjects. Significant inverse relationships between SST level and AI (r=-0.21, p＜ 0.05), or MDA (r=-0.31, p＜0.01) were observed. These results suggest a possible protective role of endogenous SST, at least on hyperlipidemia and atherosclerosis that are attributed to excess energy intake and physical inactivity. Of course these preliminary results should be supported by prospective studies.

並列關鍵字

somatostatin ； insulin resistance ； oxidative stress ； malondialdehyde ； hyperlipidemia