Chicken-based Formula Is Better Tolerated than Extensively Hydrolyzed Casein Formula for the Management of Cow Milk Protein Allergy in Infants

牛奶蛋白過敏兒對於雞肉配方的耐受性優於高度水解酪蛋白配方

Pipop Jirapinyo ； Narumon Densupsoontorn ； Channagan Kangwanpornsiri ； Renu Wongarn

《Asia Pacific Journal of Clinical Nutrition》 21卷2期 (2012/06) Pp. 209-214

https://doi.org/10.6133/apjcn.2012.21.2.06

摘要

對於牛奶過敏兒治療之組成配方，主要是將牛奶蛋白去除，改以高度水解蛋白配方或是胺基酸配方取代之。然而，使用高度水解蛋白配方之過敏兒仍約有10%未得到改善，而胺基酸配方非常昂貴。因此，本研究欲釐清，對牛奶過敏兒來說，是否使用新的雞肉配方相對於高度水解蛋白配方有較好的耐受性。共招募100位牛奶過敏兒，先經過双盲、安慰劑對照的食物攝取測試，以確定診斷。利用双盲、隨機的交叉實驗設計比較攝食高度水解蛋白配方與雞肉配方之過敏兒反應。首先受試者被隨機分派至其中一種配方組別中，持續2個星期，接著有2星期的洗滌期，在此期間內所有受試者皆攝取胺基酸配方。洗滌期過後，再交換使用另一組不同的配方，一樣維持2星期。若受試者在接受測試配方的期間，出現過敏症狀，則會被認為對於此配方有耐受不良或過敏的情形。在80位確診的受試者中，有67位的父母同意配合實驗進行，而最後共有58位完成試驗。結果發現，共38位過敏兒對於高度水解蛋白配方產生耐受不良，而有25位對於雞肉配方耐受不佳。因此本篇結論為，對牛奶過敏兒而言，雞肉配方相較於高度水解蛋白配方，其耐受性明顯較佳。

關鍵字

雞肉配方 ； 牛奶蛋白過敏 ； 高度水解蛋白配方 ； 嬰兒 ； 泰國

並列摘要

The effective treatment of cow milk allergy in infants consists of elimination of cow milk protein and the introduction of formulas based on an extensively hydrolyzed protein formula or an amino acid-based formula. However, about 10% of these infants are still allergic to an extensively hydrolyzed protein formula and an amino acid-based formula is very expensive. We conducted a study to verify whether the new chicken-based formula will be better tolerated than an extensively hydrolyzed protein formula for the treatment of cow milk allergy in infants. One hundred infants, diagnosed with cow milk allergy by double-blind, placebo-controlled food challenge tests, were enrolled in a double-blind, randomized, cross-over study to compare a response to an extensively hydrolyzed protein formula and the chicken-based formula. Subjects were randomly given one of the two formulas for 2 weeks. There was a 2-week washout period of taking an amino acid-based formula before being switched to the other formula for another 2 weeks. If the subjects showed allergic symptoms during the 2 weeks of test formula, they would be announced as intolerance or allergic to that formula. Sixty seven of 80 confirmed subjects agreed to enroll their infants. Fifty-eight subjects completed the study. Twenty and 33 infants were tolerant whereas and 38 and 25 infants were intolerant to an extensively hydrolyzed protein formula and the chicken-based formula, respectively. The chicken-based formula showed significantly better tolerance than an extensively hydrolyzed protein formula in the management of cow milk allergy in infants.

並列關鍵字

chicken-based formula ； cow milk allergy ； extensively hydrolyzed protein formula ； infant ； Thailand