Diagnostic Value of Anthropometric Indices for Initial Stage of Atherosclerosis in Adult Women

成人女性的體位測量指標對初期動脈硬化之診斷值

Motahar Heidari-Beni ； Masoud Hajimaghsood ； Mehrangiz Ebrahimi-Mamaghani ； Mohammad Asghari Jafarabadi ； Seyed Mohammad Hosein Mousavi-Jazayeri ； Javad Mohtadinia

《Asia Pacific Journal of Clinical Nutrition》 21卷2期 (2012/06) Pp. 220-226

https://doi.org/10.6133/apjcn.2012.21.2.08

摘要

體重過重是心血管疾病的危險因子。體位測量指標與心血管健康的關聯性尚未完全明瞭。頸動脈中層厚度（CIMT）是動脈硬化的臨床前期標記。此研究目的為找出以CIMT診斷的初期動脈硬化之最佳體位肥胖指標。這個橫斷性研究包含100名18-50歲的成人女性。體位測量值是依據標準流程進行測量，而CIMT則是以非侵入性的超音波測量。以接受器操作特性曲線（ROC）分析來決定體位測量指標的理想切點及動脈硬化診斷的最適指標。由ROC分析所建議的腰圍、腰臀圍比、腰圍身高比、身體質量指數（BMI）及體脂肪比率的最適切點，分別是96公分、0.86、0.64、31.29 kg/m^2及30.42。身體質量指數（AUC=0.74，95%CI=0.62-0.86）和腰圍身高比（AUC=0.74，95%CI=0.63-0.85）的ROC曲線下面積較其他體位測量指標高。腰臀圍比的曲線下面積是這些肥胖指標中最低的（AUC=0.68，95%CI=0.54-0.81）。在本研究中，依據AUC結果顯示，腰圍身高比及身體質量指數是動脈硬化初期最佳的診斷參數，而腰臀圍比是最差的。

關鍵字

體位測量指標 ； 動脈硬化 ； 頸動脈 ； 切點 ； 接受器操作特性曲線

並列摘要

Excess body weight is a cardiovascular risk factor. The relationship between anthropometric indices and cardiovascular health is not completely understood. Carotid Intima-Media Thickness (CIMT) is a subclinical marker of atherosclerosis. This study aimed to investigate the best anthropometric obesity indicator for diagnosis of initial stage of atherosclerosis by CIMT. This cross-sectional study included 100 adult women, aged 18-50 years. Anthropometric indices were measured with standard protocol and CIMT was measured by non-invasive ultrasound. Receiver Operating Characteristics (ROC) curve analysis was carried out to determine the optimal cut-off values of anthropometric indices, and the best indices for atherosclerosis diagnosis. On ROC curve analysis the suggested appropriate cut-offs of waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), body mass index (BMI) and percentage body fat (%BF) were 96 cm, 0.86, 0.64, 31.29 kg/m^2 and 30.42%, respectively. The area under the ROC curve of BMI (AUC=0.74, 95%CI=0.62-0.86) and WHtR (AUC=0.74, 95%CI=0.63-0.85) were greater than other anthropometric indices. The AUC for WHR was the lowest among the studied obesity indices AUC=0.68 (95% CI=0.54-0.81). In our study, WHtR and BMI were the best diagnostic parameters of initial stage of atherosclerosis while WHR was the worst based on AUC.

並列關鍵字

anthropometric indices ； atherosclerosis ； carotid arteries ； cut-off values ； ROC analysis