Intrauterine Nutrition and Carotid Intimal Media Thickness in Young Thai Adults

泰國年輕成人子宮內營養與頸動脈中層厚度的關聯

Kittipan Rerkasem ； Antika Wongthanee ； Amaraporn Rerkasem ； Pien Chiowanich ； Piyamitr Sritara ； Sakda Pruenglampoo ； Ampika Mangklabruks

《Asia Pacific Journal of Clinical Nutrition》 21卷2期 (2012/06) Pp. 247-252

https://doi.org/10.6133/apjcn.2012.21.2.12

摘要

數個研究顯示子宮內營養限制與成長後血管疾病具有相關性。動物實驗顯示受限的妊娠期飲食可影響後代的動脈硬化，但是這個相關性在人體仍具爭議。此研究旨在研究母親懷孕期間的飲食攝取與其子女頸動脈中層厚度（CIMT）之相關性。我們測量565名20歲年輕成人的CIMT，他們的母親在懷孕期間參加1989-1990年在泰國清邁兩間醫院執行的一個營養研究。母親孕期的飲食是以24小時飲食回憶法及食物頻率法兩種方法評估。參與者是男性或有較高的血糖值、身體質量指數及收縮壓者，呈現較高的頸動脈中層厚度。母親在第一孕期的蛋白質攝取量與CIMT的厚度為負相關（p=0.02）。這些參與者，若母親在第一孕期的蛋白質攝取量分佈在最低四分位者，其CIMT平均為0.45 mm（95%CI: 0.44-0.46），高於那些分佈在最高四分位者（0.43 mm; 95%CI: 0.42-0.44）。總而言之，母親在懷孕初期較低的蛋白質攝取量可能增加青少年的CIMT。

關鍵字

子宮內營養 ； 頸動脈中層厚度 ； 妊娠飲食 ； 血管疾病 ； 動脈硬化

並列摘要

Several studies show that intrauterine nutrition restriction is associated with vascular disease. Animal studies have shown that atherosclerosis can be affected by a constrained intrauterine diet, but this relationship in humans is controversial. The purpose of this study was to investigate the relationship between maternal intake during pregnancy and carotid intimal media thickness (CIMT). We measured CIMT in 565 twenty year old young adults whose mothers, while pregnant, participated in a nutritional study during 1989-1990 at two hospitals in Chiang Mai, Thailand. Maternal diet during pregnancy was assessed by two methods in each trimester, namely, the 24 hours food recall method and the food frequency method. Carotid intimal media thickness was greater in males and participants who showed higher blood glucose, higher body mass index and higher systolic blood pressure. Maternal protein intake during the first trimester was negative correlated with thickness of CIMT (p=0.02). The mean CIMT of participants whose mothers were in the lowest quarter of the distribution of protein intake in the first trimester was 0.45 mm (95% confidence interval (CI): 0.44-0.46) more than that of those whose mothers were in the highest quarter of the distribution (0.43 mm 95% CI: 0.42-0.44). In conclusion, lower maternal protein intake during early pregnancy may increase CIMT in adolescents.

並列關鍵字

intrauterine nutrition ； carotid intimal medial thickness ； maternal diet ； vascular disease ； atherosclerosis