Association of the Adiponectin Gene (ADIPOQ) +45 T > G Polymorphism with the Metabolic Syndrome among Han Chinese in Sichuan Province of China

中國四川省漢族居民脂聯素基因+45 T>G多態性與代謝綜合征的關聯

Xiao-Tong Li ； Da-Ying Wei ； Hui-Jing He ； Jian-Hua Zhang ； Chun-Xiu Wang ； Ming-Ju Ma ； Bin Wang ； Tao Yu ； Li Pan ； Fang Xue ； Hai-Qing He ； Wei-Wei Xu ； Ting-Fang Pan ； Qian Zuo ； Lindblad Ulf ； Guang-Liang Shan

《Asia Pacific Journal of Clinical Nutrition》 21卷2期 (2012/06) Pp. 296-301

https://doi.org/10.6133/apjcn.2012.21.2.18

摘要

The metabolic syndrome is a cluster of abnormalities characterized by obesity, impaired glucose metabolism, hypertension or elevated blood pressure, and dyslipidemia. The aim of this study was to investigate the association of the adiponectin gene (ADIPOQ) +45 T ＞ G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China. A case-control design was used including 116 patients with the metabolic syndrome and 108 unrelated controls, matched on age and gender. The ADIPOQ +45G allele (TG+GG) had a significant association with risk of the metabolic syndrome (odds ratio=1.88, 95% confidence interval: 1.03-3.44, p=0.039) adjusted for education, physical activity, family history of related diseases, smoking and drinking, compared with subjects with TT genotype. The association between the ADIPOQ +45 T＞G polymorphism and the metabolic syndrome was independent of multiple confounders.

關鍵字

代謝綜合征 ； 脂聯素基因 ； 基因多態性 ； 病例-對照研究 ； 中國

並列摘要

The metabolic syndrome is a cluster of abnormalities characterized by obesity, impaired glucose metabolism, hypertension or elevated blood pressure, and dyslipidemia. The aim of this study was to investigate the association of the adiponectin gene (ADIPOQ) +45 T ＞ G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China. A case-control design was used including 116 patients with the metabolic syndrome and 108 unrelated controls, matched on age and gender. The ADIPOQ +45G allele (TG+GG) had a significant association with risk of the metabolic syndrome (odds ratio=1.88, 95% confidence interval: 1.03-3.44, p=0.039) adjusted for education, physical activity, family history of related diseases, smoking and drinking, compared with subjects with TT genotype. The association between the ADIPOQ +45 T＞G polymorphism and the metabolic syndrome was independent of multiple confounders.

並列關鍵字

the metabolic syndrome ； ADIPOQ ； polymorphism ； case-control study ； China