Association between the Xba I Polymorphism of APOB Gene and Plasma Lipid Level in Mexican Patients with Coronary Artery Disease

罹患冠心病的墨西哥患者之脂蛋白酶元B基因Xba I多型性與血脂濃度的相關性

Martha P Gallegos-Arreola ； Yadira Valdez ； Marco Zúñiga-Corona ； Luis E Figuera ； Lisette Arnaud-López ； José A Robles-Cervantes ； Manuel González-Ortiz ； Esperanza Martínez-Abundis ； Ana M Puebla-Pérez ； Guillermo M Zúñiga-González

《Asia Pacific Journal of Clinical Nutrition》 21卷2期 (2012/06) Pp. 312-318

https://doi.org/10.6133/apjcn.2012.21.2.20

摘要

Some studies, that consider polymorphisms of the apolipoprotein B (APOB) gene as risk factors for coronary artery disease (CAD), have reported discordant results. The aim of the present study was to search for associations between plasma lipid profiles with the DNA Xba I polymorphism of the APOB gene in CAD patients diagnosed by angiography (CAD+). In the present study we compared 114 Mexican patients (80 men and 34 women) with CAD+ and 132 control patients (59 men and 73 women) without evidence of ischemia or arterial damage (CAD-). The frequency of X+/X+ genotype of Xba I polymorphism, in CAD+ group, was 23% (26/114) compared with 8% (11/132) in the CAD- (OR 3.25, p = 0.002). The patients with X+/X+ for the Xba I genotype APOB gene had higher concentration of triglycerides (TG) and VLDL in plasma than CAD- (p ＜ 0.05). The genotype X+/X+ in the CAD had an effect increasing the TG and VLDL plasma levels when compared with individuals with X-/Xand X-/X+ genotypes. The present study indicated that the X+X+ genotype of Xba I polymorphism is associated with CAD+ patients and high plasma levels of TG and VLDL, in the Mexican population.

關鍵字

脂蛋白酶元B ； 膽固醇 ； 基因多型性 ； 血脂 ； 墨西哥人

並列摘要

Some studies, that consider polymorphisms of the apolipoprotein B (APOB) gene as risk factors for coronary artery disease (CAD), have reported discordant results. The aim of the present study was to search for associations between plasma lipid profiles with the DNA Xba I polymorphism of the APOB gene in CAD patients diagnosed by angiography (CAD+). In the present study we compared 114 Mexican patients (80 men and 34 women) with CAD+ and 132 control patients (59 men and 73 women) without evidence of ischemia or arterial damage (CAD-). The frequency of X+/X+ genotype of Xba I polymorphism, in CAD+ group, was 23% (26/114) compared with 8% (11/132) in the CAD- (OR 3.25, p = 0.002). The patients with X+/X+ for the Xba I genotype APOB gene had higher concentration of triglycerides (TG) and VLDL in plasma than CAD- (p ＜ 0.05). The genotype X+/X+ in the CAD had an effect increasing the TG and VLDL plasma levels when compared with individuals with X-/Xand X-/X+ genotypes. The present study indicated that the X+X+ genotype of Xba I polymorphism is associated with CAD+ patients and high plasma levels of TG and VLDL, in the Mexican population.

並列關鍵字

apolipoprotein B ； cholesterol ； polymorphism ； plasma lipids ； Mexican