Glutamine for Chemotherapy Induced Diarrhea: A Meta-Analysis

谷氨酰胺在预防化疗相关性腹泻中的临床疗效仍存在争议，因此本次荟萃分析纳入了尽可能多的临床随机对照研究，来明确谷氨酰胺在预防化疗性腹泻中的疗效。方法：搜索EMBASE数据库、Medline数据库、Cochrane图书馆和BIOSIS数据库，所有比较谷氨酰胺与安慰剂对预防化疗相关性腹泻作用的随机对照研究均纳入本次荟萃分析。主要分析结果为腹泻评分和腹泻天数。结果：8个随机对照研究，共298名患者纳入了本次研究，其中谷氨酰胺组147名，安慰剂对照组151名。两组腹泻天数有很大差别（WMD，-1；95%可信区间：-1.73，-0.26），但是腹泻评分无明显差别（WMD，-0.49；95%可信区间：-1.73，0.39）。结论：谷氨酰胺可以减少化疗相关性腹泻的天数，但可能无法减轻腹泻程度。

關鍵字

谷氨酰胺；腹泻；化疗；荟萃分析；预防性

並列摘要

The clinical efficacy of glutamine in the control of chemotherapy-induced diarrhea remains controversial. We conducted a meta-analysis, including as many randomized control trails (RCTs) as possible, to clarify the effectiveness of prophylactic glutamine in patients requiring chemotherapy. Methods: the Embase, MEDLINE, Cochrane Library, and BIOSIS databases were searched, and the included studies were RCTs that compared the use of prophylactic glutamine versus placebo in patients receiving chemotherapy. The main outcomes were diarrhea severity and duration. Results: a total of 298 patients in eight RCTs were reviewed (147 patients who received glutamine, and 151 patients who received placebo). There was a statistically significant difference in the duration of diarrhea (weighted mean difference (WMD), -1; 95% confidence interval (CI), -1.73, -0.26) between the two groups, but there was no significant difference in the severity of diarrhea (WMD, -0.49; 95% CI, -1.36, 0.39) between the groups. Conclusion: we concluded that glutamine could reduce the duration of diarrhea but could not improve its severity.

並列關鍵字

glutamine ； diarrhea ； chemotherapy ； meta-analysis ； prophylactic

國際替代計量

Glutamine for Chemotherapy Induced Diarrhea: A Meta-Analysis

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