- 期刊
Isoflavone Consumption and Risk of Breast Cancer: A Dose-Response Meta-Analysis of Observational Studies
大豆异黄酮摄入量与乳腺癌发生风险的关系：观察性研究剂量反应的整合分析
摘要
关于大豆异黄酮的摄入能否预防乳腺癌发生风险的流行病学研究结论不一致，而争议主要集中在大豆异黄酮的摄入时间不同和暴露剂量差异对乳腺癌的发生风险是否有影响。研究目标是通过整合分析，探讨大豆异黄酮摄入量与目标人群乳腺癌发生风险的关系。通过检索PubMed和EMBASE数据库中的病例对照研究和队列研究，评估大豆异黄酮摄入量与乳腺癌发生风险的关联。从每一项研究中，提取大豆异黄酮摄入量和对应的相对危险度（RR）或者比值比（OR），利用固定或随机效应模型来评估剂量反应数据。结果符合入选标准的研究有22项。经整合分析后得出，高剂量的大豆异黄酮摄入在亚洲人群（合并RR/OR: 0.68, 95％CI: 0.52-0.89）的效果要好于西方人群（RR/OR: 0.98, 95％CI: 0.87-1.11）。进一步的分析表明，亚洲女性绝经后（RR/OR: 0.46, 95％CI: 0.28-0.78）摄入异黄酮预防乳腺癌的效果好于绝经前摄入（RR/OR: 0.63, 95%CI: 0.50-0.80)，而西方女性中绝经后（RR/OR: 1.00, 95%CI: 0.98-1.02）摄入异黄酮预防乳腺癌的效果与绝经前摄入（RR/OR: 0.99, 95%CI: 0.87-1.12)无显著差别。因此，高剂量的异黄酮摄入在亚洲人群中可能降低乳腺癌的发生风险，尤其是在绝经后女性中。然而在西方人群的研究中没有发现显著的差异，可能是由于西方人群异黄酮的摄入量较低。
並列摘要
Epidemiologic studies that examine whether isoflavone consumption protects against breast cancer have yielded inconsistent results. The controversy focuses on the effects of the menopausal status and exposure dose of isoflavone. We aim to conduct a meta-analysis on the association between isoflavone intake and breast cancer risk by comprehensively assessing isoflavone exposure in the targeted populations. We searched PUBMED and EMBASE databases for case-control and cohort studies that assess the association between isoflavone intake and breast cancer risk. We extracted relative risks (RR) and odds ratios (OR) of different reported categories of isoflavone intake from each study. Fixed- or random-effects models were used to summarize dose-response data. Twenty-two studies were selected for the meta-analysis. Overall, the results showed that isoflavone reduced the breast cancer risk (a combined RR/OR of 0.68, 95% CI: 0.52-0.89) in Asian populations rather than Western populations (a combined RR/OR of 0.98, 95% CI: 0.87, 1.11) for the high-dose category. Further analysis showed that the intake of isoflavone in postmenopausal Asian women 0.46 (95% CI: 0.28-0.78) was better than premenopausal 0.63 (95% CI: 0.50-0.80) but similar in postmenopausal Western women 1.00 (95% CI: 0.98-1.02) and premenopausal 0.99 (95% CI: 0.87-1.12). Exposure to high isoflavone may be associated with a reduced breast cancer risk in Asian populations, especially in postmenopausal women. However, no significant difference in the studies of Western populations may be due to the low intake of isoflavone levels.
參考文獻
延伸閱讀
- 張雅娟（2019）。大豆異黃酮genistein及daidzein對於potassium oxonate和uric acid誘發高血尿酸小鼠發炎作用及胰島素阻抗之影響〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU201900201
- Pusparini, Dharma, R., Suyatna, F. D., Mansyur, M., & Hidajat, A. (2013). 大豆異黃酮補充劑對於停經後婦女血管內皮細胞功能及氧化壓力的影響：社區隨機對照試驗. Asia Pacific Journal of Clinical Nutrition, 22(3), 357-364. https://doi.org/10.6133/apjcn.2013.22.3.13
- Pusparini, Dharma, R., Suyatna, F. D., Mansyur, M., & Hidajat, A. (2013). 大豆異黃酮補充劑對於停經後婦女血管內皮細胞功能及氧化壓力的影響：社區隨機對照試驗. Asia Pacific Journal of Clinical Nutrition, (), 2-9. https://www.airitilibrary.com/Article/Detail?DocID=09647058-201303-PP201303130005-PP201303130005-2-9-0001
- 鄭筱翎（2003）。大豆異黃酮素抑制癌細胞移行及其細胞凋亡機制之探討〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-0707200816054358
- 陳妍蓁（2016）。不同種類有機肥對大豆性狀與異黃酮含量之研究〔碩士論文，國立屏東科技大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0042-1805201714165799