The Association of Weight Status with Cognitive Impairment in the Elderly Population of a Shanghai Suburb

上海郊区老年人群体重与认知功能障碍的关系

Guo-Hong Cui ； Hai-Dong Guo ； Rui-Fang Xu ； Guo-Xin Jiang ； Sheng-Di Chen ； Qi Cheng

《Asia Pacific Journal of Clinical Nutrition》 22卷1期 (2013/03) Pp. 74-82

https://doi.org/10.6133/apjcn.2013.22.1.18

摘要

目的：研究上海郊区2个镇的老年人群低体重、血压、血糖、血脂与认知功能障碍之间的关系。方法：由经过培训的调查人员采用认知功能障碍调查问卷，对研究对象进行面对面的询问，收集相关资料。並進行对身体的测量，包括身高、体重、腰围及臀围。通过非条件多因素逻辑回归分析研究体重、血压、血糖、血脂与认知功能障碍的关系。结果：2,809人的研究对象中，有198（7.0%）人被诊断为认知功能障碍。在调整了可能的混杂因素后，与正常体重指数(BMI)人群相比，低体重与认知功能障碍之间存在相关关系（OR= 2.47，95%CI: 1.46-5.23）；与正常腰围组相比，高腰围与认知功能障碍之间存在相关关系（OR= 1.42，95%CI: 1.10-2.67）；与正常腰臀比（WHR）组相比，高腰臀比与认知功能障碍之间亦存在相关关系（OR= 1.68，95%CI: 1.05-2.84）。本研究结果表明，高血压、血脂异常可能通过与腰围、腰臀比之间的交互作用对认知功能障碍的发生产生影响。结论：中心型肥胖与认知功能障碍之间存在相关关系。低体重可能是认知功能障碍的危险因素。高血压、血脂异常与腰围、腰臀比之间存在交互作用。

關鍵字

认知功能障碍 ； 腰围 ； 腰臀比 ； 体重指数

並列摘要

Objective: A population-based survey was conducted to analyze the association of under-weight, blood pressure, glucose and lipid metabolism with cognitive impairment in people, 60 years and over, living in 2 towns of Shanghai. Methods: Face-to-face interviews were carried out to collect relevant information with questionnaires. Anthropometric indices of height, weight, waist circumference (WC) and hip circumference were measured. Multivariable logistic regression analyses were performed to evaluate the association of weight status with cognitive impairment. Results: Cognitive impairment were diagnosed in 198 (7.0%) of the 2 809 participants. Compared to the normal BMI category, the under-weight category was significantly associated with the risk of cognitive impairment (OR=2.47, 95%CI: 1.46-5.23). Subjects with a high WC were 1.5 times (OR=1.42, 95%CI: 1.10-2.67) more likely and subjects with a high WHR were 1.7 times (OR=1.68, 95%CI: 1.05-2.84) more likely to be associated with cognitive impairment than the subjects in the reference group. This study demonstrates a significant interaction between hypertension, lipid disorder and WC or WHR on the risk of cognitive impairment in a rural population in Shanghai. Conclusions: Central obesity was significantly associated with the risk of cognitive impairment. A low BMI may be a risk factor for cognitive impairment. A significant interaction between hypertension, lipid disorder and WC or WHR on the risk of cognitive impairment in Shanghai rural population was found.

並列關鍵字

cognitive impairment ； waist circumference ； waist-to-hip ratio ； BMI

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