Maternal Serum Lipid Levels during Late Pregnancy and Neonatal Body Size

目的：是探讨妊娠晚期母体的血脂水平对新生儿出生体重的预测价值。方法：本研究是从2011年1月到2012年7月在一个妇幼保健院实施的，在孕妇分娩前测定母体的空腹血糖、甘油三酯、胆固醇、高密度脂蛋白和低密度脂蛋白水平，并测量新生儿的人体学资料。结果：大于胎龄儿的母亲与正常母亲相比，年龄更大、身高更高、妊娠前体重和体质指数更高。在调整了母亲的年龄、妊娠前体质指数、孕期增重、产次、新生儿性别和分娩孕周后，妊娠晚期母体的高密度脂蛋白水平与新生儿的出生体重、身长和头围成负相关（p＜0.05）．Logistic回归分析发现，在调整混杂因素后，大于胎龄儿的预测因子是妊娠晚期母体高密度脂蛋白水平（OR 0.57, 95% CI: 0.38-0.84）。结论：我们认为母体妊娠晚期的高密度脂蛋白水平与新生儿出生体重独立相关，是大于胎龄儿的独立预测因子。

關鍵字

血脂；出生体重；孕期；甘油三酯；大于胎龄儿

並列摘要

Objective: The aim of this study was to determine the predictive value of maternal serum lipid levels during late pregnancy for neonatal body size. Methods: This study was conducted from January 1, 2011 to July 31, 2012 at a Maternal and Child Health Hospital. Fasting blood glucose, serum triglyceride, total cholesterol, HDL and LDL were estimated in maternal collected before delivery. Detailed anthropometry of the neonates was performed. Results: Women who delivered a large for gestational age baby were older, taller, had a higher pre-pregnancy weight, higher pre-pregnancy BMI, and higher weight gain during pregnancy than women who delivered an appropriate for gestational age infant. After adjusting for maternal age, pre-pregnancy BMI, weight gain during pregnancy, parity, neonatal sex and gestational age at delivery, we found that only maternal HDL level was inverse associated with birth weight, length and head circumference (p＜0.05). On logistic regression analysis, the significant metabolic predictors of large for gestational age was HDL (OR 0.57, 95%CI: 0.38-0.84, per 1 mmol/L increase) after adjusting for the confounders. Conclusions: Maternal serum HDL level determined in maternal blood taken close to delivery was independently associated with neonatal size and was the independent predictor for large for gestational age.

並列關鍵字

lipids ； birth weight ； pregnancy ； triglycerides ； large for gestational age

國際替代計量

Maternal Serum Lipid Levels during Late Pregnancy and Neonatal Body Size

全文下載

主題瀏覽