Correction of hypovitaminosis D does not improve the metabolic syndrome risk profile in a Chinese population: a randomized controlled trial for 1 year

纠正维生素D缺乏没有改善代谢综合征患者的心血管危险因素：中国的一项前瞻性随机对照試驗

Xiao Yin ； Ling Yan ； Yong Lu ； Qiang Jiang ； Ying Pu ； Qiang Sun

《Asia Pacific Journal of Clinical Nutrition》 25卷1期 (2016/01) Pp. 71-77

https://doi.org/10.6133/apjcn.2016.25.1.06

摘要

背景与目的：维生素D缺乏与许多慢性代谢性疾病相关。研究证实血清维生素D水平与肥胖症及其相关代谢异常有重要的相关关系，但目前针对中国人群维生素D缺乏研究的数据还相对匮乏。本研究选择中国北方地区城市中年人群，研究维生素D干预治疗对代谢综合征的影响。研究设计与方法：在体检人群中筛选代谢综合征合并维生素D缺乏者126例，随机分为干预治疗组和安慰剂对照组，治疗组每天口服700IU维生素D，在基线及干预12月后检测两组代谢指标。结果：维生素D干预治疗组12月后血清25(OH)D水平显著升高，血清甲状旁腺激素水平显著下降。但体重指数、血压、血糖、血脂等代谢性指标两组在干预前后都没有显著差异。结论：在中国城市中年人群中补充维生素D可纠正其缺乏状态，但并没有显著改善代谢综合征的各种代谢异常。以后需进一步深入相关研究阐明维生素D状态与肥胖及相关代谢异常发生之间的因果关系。

關鍵字

维生素D缺乏 ； 代谢综合征 ； 维生素D补充 ； 肥胖症 ； 中国

並列摘要

Background and Objectives: Vitamin D deficiency is associated with a variety of chronic metabolic diseases. In vitro and animal studies suggest that vitamin D may play a crucial role in obesity and related metabolic disorders. Limited evidence regarding vitamin D deficiency exists within the Chinese population. The aims of the present study were to assess whether supplementation with vitamin D would improve metabolic indices in a middle-aged urban Chinese population. Methods and Study Design: We designed a randomized placebo controlled trial involving 126 metabolic syndrome sufferers with vitamin D deficiency, allocated to receive either a daily oral tablet contain 700 IU vitamin D or a matching placebo. Metabolic indices including body mass index, plasma glucose, lipid profile and other parameters were measured in subjects who completed a 12 months intervention trial. Results: There were significantly higher serum 25(OH)D and lower serum parathyroid hormone in vitamin D treatment group after the 12 months intervention, but no significant effect was observed for the metabolic variables which included body mass index, blood pressure, blood glucose and lipids in both treatment and control groups. Conclusions: Correction of hypovitaminosis D did not improve the metabolic syndrome in this urban Chinese cohort. Further studies are warranted in order to elucidate the cause-effect relation between vitamin D status, obesity and related metabolic disorders.

並列關鍵字

vitamin D deficiency ； metabolic syndrome ； vitamin D supplementation ； obesity ； Chinese