Relationship between bone mineral density and alcohol consumption in Korean men: the Fourth Korea National Health and Nutrition Examination Survey (KNHANES), 2008-2009

背景与目的：饮酒是骨质疏松的一个危险因素，但关于饮酒和骨密度（BMD）之间的关系却存在争议。我们对饮酒和BMD之间的关系进行了分析。方法与研究设计：在2008-2009年参加韩国第四次全国健康与营养调查的2421名年龄在40-93岁的男性中进行横断面研究。酒精摄入量由自填问卷确定，BMD的测量采用双能X射线吸收法测量。采用方差分析确定饮酒和BMD的关系，采用协方差分析校正年龄、体质指数、教育、家庭收入、吸烟、钙的摄入量、体力活动和血清25-羟基维生素D的浓度。结果：随着酒精摄入量的增加，腰椎、全股骨和股骨颈的BMD显著增加（p-趋势分别为0.028、＜0.001 和＜0.001）。然而，校正年龄之后，这三个部位与饮酒的关系不再有统计学意义（腰椎、全股骨和股骨颈的p-趋势分别为0.606、0.342 和0.549）。此外，在校正了其他所有的混杂因素之后，这三个部位与饮酒之间也没有显著关系（腰椎、全股骨和股骨颈的p-趋势分别为0.451、0.150 和0.343）。根据年龄、吸烟、体力活动或肥胖分层分析，也没有发现饮酒与BMD之间有显著关系。结论：校正年龄和其它混杂因素之后，饮酒与BMD之间没有显著的关系。

關鍵字

骨质疏松；酒精；骨密度；韩国男性

並列摘要

Background and Objectives: Drinking is a risk factor of osteoporosis, but controversy surrounds the relationship between alcohol consumption and bone mineral density (BMD). We performed an analysis of the association between alcohol consumption and BMD. Methods and Study Design: A cross-sectional study was performed including 2421 men, aged 40-93 years, who participated in the fourth Korea National Health and Nutrition Examination Survey in 2008-2009. Alcohol intake was determined by self-administered questionnaires, and BMD was measured by dual energy x-ray absorptiometry. ANOVA was used to determine the relationship between alcohol intake and BMD, and ANCOVA was performed after adjusting for age, body mass index, education, household income, smoking status, calcium intake, physical activity, and serum 25-hydroxyvitamin D levels. Results: BMD increased significantly in the lumbar spine, total femur, and femoral neck with increased alcohol intake (p for trend=0.028, ＜0.001, ＜0.001, respectively). However, after adjusting for age, the relation was no longer statistically significant in any of 3 bone sites (lumbar, p for trend=0.606; total femur, p for trend=0.342; femoral neck, p for trend=0.549). Additionally, after adjusting for all other confounders, no significant relationships were reported in the 3 bone sites (lumbar, p for trend=0.451; total femur, p for trend=0.150; femoral neck, p for trend=0.343). In the stratified analysis, there were no significant correlations according to age, smoking status, physical activity or obesity. Conclusions: After adjusting for age and other confounders, no significant relationship was found between alcohol intake and BMD.

並列關鍵字

osteoporosis ； alcohol ； bone mineral density ； KNHANES ； Korean men

國際替代計量

Relationship between bone mineral density and alcohol consumption in Korean men: the Fourth Korea National Health and Nutrition Examination Survey (KNHANES), 2008-2009

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