Food intolerance prevalence in active ulcerative colitis in southwest China

中国西南地区急性溃疡性结肠炎患者食物不耐受流行情况

Xin-Ling Ma ； Yuke Chen ； Fang-Yan Huang ； Qian-Ying Luo ； Hui Lv ； Hua Long

《Asia Pacific Journal of Clinical Nutrition》 25卷3期 (2016/09) Pp. 529-533

https://doi.org/10.6133/apjcn.102015.04

摘要

背景与目的：溃疡性结肠炎与患者的饮食模式密切相关，食物不耐受被认为是溃疡性结肠炎患者频繁就医的原因。生活在中国欠发达地区，中国西南地区居民有着不同的饮食习惯。本研究的目的是确定中国西南地区急性溃疡性结肠炎患者食物不耐受的患病率，并探讨导致该情况的可能危险因素。方法与研究设计：运用酶联免疫法检测80名急性期溃疡性结肠炎患者血清特定食物抗体水平，通过调查问卷获取患者饮食模式及人口学资料并分析。结果：本研究83.8%（67/80）患者食物不耐受检测阳性，年龄介于20至40岁倾向于高脂饮食的女性患者血清食物抗体水平明显高（p＜0.05)，主食种类、辛辣饮食、病史等因素组间差别无统计学意义（p＞0.05)。结论：中国西南地区急性溃疡性结肠炎患者食物不耐受阳性率高，尤以女性及中青年患者明显。高脂饮食模式与食物不耐受显著相关。本研究未发现桂西地区以大米为主食、喜食辛辣等饮食习惯与患者食物不耐受情况有明显联系。

關鍵字

食物不耐受 ； 溃疡性结肠炎 ； 血清阳性 ； 饮食模式

並列摘要

Background and Objectives: Food intolerance is believed to be a source of frequent medical problems in ulcerative colitis (UC), which closely correlate with patients' dietary pattern. Living in an underdeveloped area of China, residents in southwestern region have diverse dietary habits. The objective of this study is to determine the prevalence of food intolerance in the UC patients in this area and to discuss some of the possible risk factors leading to the condition. Methods and Study Design: Food antibodies in serum of 80 patients with active UC were determined by standard enzyme-linked immuno sorbent assay (ELISA). This study examined the risk factors contributing to high titers of food antibodies and the dietary patterns correlating with food intolerance in these demographics. Results: 83.8% of patients (67/80) were found to be seropositive for food intolerance. Patients of female, aged between 20 to 40 and the one who tended to have a high fat diet were tested to be highly seropositive (p＜0.05). Neither spicy food intake nor the course the disease manifested any relationship with the presence of food intolerance (p＞0.05). Conclusion: Active UC patients in southwestern region of China have showed to be high seropositive in food intolerance, particularly in female and young patients. Dietary patterns with high in fat intake seem to have caused high prevalence of seropositivity in food intolerance. Although rice has been taken as staple food and the spicy food has been popular among citizen in this region, these foods have indicated to no effect on food intolerance in this study.

並列關鍵字

food intolerance ； ulcerative colitis ； seropositive ； dietary patterns