Interaction of Dietary Carbohydrate, Protein and Marginal Copper on Lipid Metabolism in Rats

不同來源的醣類、蛋白質及邊緣性缺銅對老鼠脂質代謝的影響

胡雪萍(Shene-Pin Hu) ； 陳師瑩(Shih-Ying Chen) ； 謝明哲(M. J. Shieh)

《中華民國營養學會雜誌》 21卷3期 (1996/08) Pp. 249-262

https://doi.org/10.6691/JCNS.199608_21(3).0003

摘要

A study was conducted to explore the effects of the Chinese diet on lipid metabolism. Male weaning Sprague-Dawley rats (N=40) were fed purified diets for 7 weeks. These diets varied in carbohydrate (rice or corn starch, 62.2%), protein (casein or soybean, 15%) and copper (2.5-8ppm) in a 2×2×2 factorial design. Rats receiving marginal levels of copper had significantly lower final body weights and feed efficiencies compared to rats fed adequate levels of copper (p＜0.05). The total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) levels in serum were lower in rats fed rice starch with casein or soy protein diets compared to rats fed corn starch (p＜0.05). Serum triglyceride levels were affected by copper levels (p＜0.001). High density lipoprotein-cholesterol (HDL-C)/TC was higher in rats fed rice starch/soyprotein than in rats fed other diets. Groups receiving marginal levels of copper exhibited characteristic signs of copper deficiency: reduced serum copper, hypoceruloplasminemia, and higher relative heart weights (p＜0.05). Liver total lipids and cholesterol were influenced by dietary factors; rice starch/soy protein groups had lower values than corn starch/casein groups (p＜0.05). Copper adequate groups had lower total liver cholesterol than did the marginal copper groups (p＜0.003). In conclusion, the growth and liver cholesterol level of rats were influenced by marginal copper level. Rice starch/soybean diet have protective effects on it.

關鍵字

邊緣性缺銅 ； 米澱粉 ； 酪蛋白 ； 黃豆蛋白 ； 膽固醇

並列摘要

A study was conducted to explore the effects of the Chinese diet on lipid metabolism. Male weaning Sprague-Dawley rats (N=40) were fed purified diets for 7 weeks. These diets varied in carbohydrate (rice or corn starch, 62.2%), protein (casein or soybean, 15%) and copper (2.5-8ppm) in a 2×2×2 factorial design. Rats receiving marginal levels of copper had significantly lower final body weights and feed efficiencies compared to rats fed adequate levels of copper (p＜0.05). The total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) levels in serum were lower in rats fed rice starch with casein or soy protein diets compared to rats fed corn starch (p＜0.05). Serum triglyceride levels were affected by copper levels (p＜0.001). High density lipoprotein-cholesterol (HDL-C)/TC was higher in rats fed rice starch/soyprotein than in rats fed other diets. Groups receiving marginal levels of copper exhibited characteristic signs of copper deficiency: reduced serum copper, hypoceruloplasminemia, and higher relative heart weights (p＜0.05). Liver total lipids and cholesterol were influenced by dietary factors; rice starch/soy protein groups had lower values than corn starch/casein groups (p＜0.05). Copper adequate groups had lower total liver cholesterol than did the marginal copper groups (p＜0.003). In conclusion, the growth and liver cholesterol level of rats were influenced by marginal copper level. Rice starch/soybean diet have protective effects on it.

並列關鍵字

marginal copper ； rice starch ； casein ； soyprotein ； cholesterol