- 期刊
- OpenAccess
Effect of Weight Reduction on Serum Uric Acid, Urinary Excretion of Uric Acid and Insulin Resistance in Obese Individuals
肥胖者體重減輕對血清尿酸、尿酸排泄以及胰島素抗性的影響
摘要
Hyperuricemia has been found to exist in obese individuals. It has been shown that subjects with hyperuricemia are characterized by insulin resistance and hyperinsulinemia. The purpose of this study was to investigate the relationship of serum uric acid concentration, insulin resistance and the associated metabolic variations in a group of obese subjects. We also studied the effect of losing 10% of initial weight on serum and urinary excretion of uric acid. Forty six obese subjects with mean body mass index 29.9±0.53 kg/m^2 were studied at Tri-Service General Hospital. The resistance to insulin-mediated glucose uptake (as defined by SSPG concentrations during insulin suppression test) and serum uric acid concentration were highly correlated (r=0.524; P＜0.001). Serum uric acid concentrations were negatively associated with urinary clearance of uric acid divided by clearance of creatinine (CUA/CCr) (r=-0.45; P＜0.001). Mean value of serum uric acid in 21 subjects who lost 10% of initial weight decreased significantly (0.34±0.02 mmol/L vs. 0.30±0.01 mmol/L; P＜0.002), insulin resistance improved (SSPG: 13.58±0.53 mmol/L vs. 9.67±0.72 mmol/L, P＜0.0001) while values of urinary CUA/CCr ratio remained unchanged. We concluded that serum uric acid levels were related to degree of insulin resistance in a group of Chinese obese subjects. Weight loss for 10% of initial weight led to decrease of serum uric acid levels and improvement of insulin resistance.
並列摘要
Hyperuricemia has been found to exist in obese individuals. It has been shown that subjects with hyperuricemia are characterized by insulin resistance and hyperinsulinemia. The purpose of this study was to investigate the relationship of serum uric acid concentration, insulin resistance and the associated metabolic variations in a group of obese subjects. We also studied the effect of losing 10% of initial weight on serum and urinary excretion of uric acid. Forty six obese subjects with mean body mass index 29.9±0.53 kg/m^2 were studied at Tri-Service General Hospital. The resistance to insulin-mediated glucose uptake (as defined by SSPG concentrations during insulin suppression test) and serum uric acid concentration were highly correlated (r=0.524; P＜0.001). Serum uric acid concentrations were negatively associated with urinary clearance of uric acid divided by clearance of creatinine (CUA/CCr) (r=-0.45; P＜0.001). Mean value of serum uric acid in 21 subjects who lost 10% of initial weight decreased significantly (0.34±0.02 mmol/L vs. 0.30±0.01 mmol/L; P＜0.002), insulin resistance improved (SSPG: 13.58±0.53 mmol/L vs. 9.67±0.72 mmol/L, P＜0.0001) while values of urinary CUA/CCr ratio remained unchanged. We concluded that serum uric acid levels were related to degree of insulin resistance in a group of Chinese obese subjects. Weight loss for 10% of initial weight led to decrease of serum uric acid levels and improvement of insulin resistance.