淋巴細胞次群比例在健康人及重症或末期口腔癌症患者的評估

Evaluation of Lymphocyte Subsets in Healthy Subjects and Patients with Advanced or Terminal Oral Cancer

林倩伶(Chien-Ling Lin) ； 李正喆(Jang-Jaer Lee) ； 章浩宏(Hao-Hueng Chang) ； 鄭景暉(Jiiang-Huei Jeng) ； 郭英雄(Ying-Shiung Kuo)

《中華牙醫學雜誌》 23卷5期 (2004/10) Pp. 379-385

https://doi.org/10.7105/CDJ.200410.0379

摘要

Lymphocyte subsets in the peripheral blood of healthy Taiwan adults were analyzed using flow cytometry. In the future, we hope to establish baseline information of lymphocyte subsets in Taiwanese. These data (28 adults, including 14 males and 14 females, aged 23~70 years old) on lymphocyte subsets included the population of helper T cells (CD4+ /CD3+), suppressor/cytotoxic T cells (CD8+ADD3+), B cells (CD19+), NK cell (CD56+), and the helper/suppressor T cells ratio (CD4+/CD8+). Differences in the populations of B cells and NK cells between males and females were observed. Populations of B cells (11.9%) and NK cells (7.4%) in females were significantly lower than there of males (16.3% for B cells and 9.3% for NK cells. In this study, T-helper cells (CD4+ADD3+) and the CD4+/CD8+ ratio were higher in females than males. Moreover, the CD4+/DD3+ and CD19+ lymphocyte subsets in 5 terminal oral cancer patients were found to be decreased. This information about cell-mediated immunity in adult healthy Taiwanese and advanced oral cancer patients is essential for our future investigations on immune changes in different stages of oral carcinogenesis.

關鍵字

淋巴細胞 ； 口腔癌 ； 流式細胞義

並列摘要

Lymphocyte subsets in the peripheral blood of healthy Taiwan adults were analyzed using flow cytometry. In the future, we hope to establish baseline information of lymphocyte subsets in Taiwanese. These data (28 adults, including 14 males and 14 females, aged 23~70 years old) on lymphocyte subsets included the population of helper T cells (CD4+ /CD3+), suppressor/cytotoxic T cells (CD8+ADD3+), B cells (CD19+), NK cell (CD56+), and the helper/suppressor T cells ratio (CD4+/CD8+). Differences in the populations of B cells and NK cells between males and females were observed. Populations of B cells (11.9%) and NK cells (7.4%) in females were significantly lower than there of males (16.3% for B cells and 9.3% for NK cells. In this study, T-helper cells (CD4+ADD3+) and the CD4+/CD8+ ratio were higher in females than males. Moreover, the CD4+/DD3+ and CD19+ lymphocyte subsets in 5 terminal oral cancer patients were found to be decreased. This information about cell-mediated immunity in adult healthy Taiwanese and advanced oral cancer patients is essential for our future investigations on immune changes in different stages of oral carcinogenesis.

並列關鍵字

lymphocyte ； oral cancer ； flow cytometry