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Carbamazepine and Its Metabolites in Epileptic Patients
Carbamazepine和其代謝物在癲癇患者上的研究
摘要
Carbamazepine現正廣泛地使用在癲癇病患，本研究係設計利用薄膜色層分析檢驗病人腦脊髓液和血清中Carbamazepine和其主要代謝物10,11-epoxy-carbamazepine，10,11-dihydro-10,11-dihydroxy-Carbamazepine的濃度，觀察他們在治療上的效果和副作用。本研究發現顯示，服用Carbamazepine後，病患的代謝物濃度和治療效果有密切的關係。
關鍵字
無資料並列摘要
This study was undertaken in an attempt to assess the role of the metabolites of carbamazepine, i.e. 10, 11-epoxy-carbamazepine and 10, 11-dihydro-10, 11-dihydroxy-carba-mazepine, with regard to their therapeutic efficacy and the occurrence of side effects of the parent drug. It was also designed to seek a possible explanation as to why certain patients with optimal levels of carbamazepine in plasma fail to respond to therapy. A total of 23 epileptic patients suffering from either generalized or partial complex seizures were chosen for this study. The results showed an association of high levels of metabolites with poor response to carbamazepine therapy. The non-response of carbamazepine in the patients with optimal level of carbamazepine plasma level may be due to competition by inactive dihydroxy metabolite to the site(s) action of the parent drug in the brain.