Primary Malignant Fibrous Histiocytoma of the Lung: A Case Report and Review of the Literature

我們提出一病例－原發性肺部惡性纖維組織細胞瘤，有一成年女性抱怨胸痛，咳嗽，呼吸急促，及間歇性咳血達二個月之久。胸部X光及電腦斷層檢查顯示肺部左下葉有一周圍清楚大小約五公分腫瘤，因其影像學檢查呈現軟組織質性及周圍鈣化，故術前臆斷為良性瘤（如hamartoma過誤瘤）。然而，因有腫瘤局部橫隔膜黏連，惡性瘤機會大大提高，因此，執行手術切除。冰凍切片快速診斷為惡性肉瘤，故施行肺左下葉切除。最終病理檢查確定為肺部惡性纖維細胞瘤。因臨床全身檢查均無原發性瘤，所以我們一致認為是一極為罕見本的原發性肺部惡性纖維組織細胞瘤。我們提出的目的是：肺部原發性惡性纖維組織細胞瘤極為罕見，在1997年以前英文文獻僅有53例，此例為本院首例。另外影像檢查看起來似為良性瘤的肺部病灶，仍有切片的必要，以免延誤治療契機。

關鍵字

肺部腫瘤；肉瘤；惡性纖維組織細胞瘤

並列摘要

A rare case of primary malignant fibrous histocytoma of the lung is reported. An adult woman complained cough, chest pain, shortness of breath, and intermittent hemoptysis for more than 2 months. Roentgenogram including chest plain film and computed tomogram revealed a well defined, 5-cm mass with soft tissue in density in the left lower lobe. The preoperative diagnosis was suspected to be a benign lesion and in favor of a hamartoma. The frozen section during surgical removal revealed a malignant spindle tumor. Therefore, lobectomy was performed. Histological examination and a immunohistochemical study confirmed the diagnosis of malignant fibrous histiocytoma (MFH). Since primary MFH in lung is very rare, almost is metastatic or radiation induced, the differential diagnosis of primary pulmonary neoplasm is important.

並列關鍵字

lung neoplasm ； sarcoma ； malignant fibrous histiocytoma

國際替代計量

Primary Malignant Fibrous Histiocytoma of the Lung: A Case Report and Review of the Literature

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