The combination of gastrointestinal (GI) symptoms and chronic interstitial cystitis complicated with hydroureteronephrosis is rare in SLE patients. We report the case of a 37-year-old woman with documented systemic lupus erythematosus (SLE) who presented with frequent urination (more than 30 times per day in small volumes), nocturia, suprapubic pain, GI symptoms, and renal insufficiency. These symptoms were associated with severe bilateral hydroureteronephrosis and a contracted bladder. Radiographs showed stricture of the ureterovesical junction. Pathologic investigations of the bladder revealed interstitial cystitis (IC). The patient's GI symptoms and dysuria improved with intravenous prednisolone therapy and central parenteral nutrition (CPN) supplementation, but persistent obstructive uropathy (OU) and renal insufficiency were noted.