Solid-state diffusion bonding of a equiaxed grain Ni-based superalloy to a directional solidified columnar grain Ni-based superalloy was carried out through hot isostatic pressing and the interface structure and properties of the joint were investigated. The results showed that the structure of bonding interface was highly dense and the γ matrix and γ’ phase were bonding perfectly by the diffusion between atom to atom. The results of room-temperature tensile tests showed that the strength of equiaxed grain was higher than directional solidified columnar grain and the fracture was on the side of directional solidified columnar grain. In 760℃ tensile tests, the strength of directional solidified columnar grain was higher than that of equiaxed grain, resulting in the fracture was on the side of equiaxed grain.