- 期刊
Nephrotoxicity Related to 5-Aminosalicylic Acid Treatment for Ulcerative Colitis: Report of a Case
以5-ASA治療潰瘍性大腸炎併發腎毒性：病例報告
摘要
多年來5-ASA已被當作治療潰瘍性大腸炎的標準用藥，然而仍然有少數幾例有關腎臟傷害的病例被報導。一位29歲的男性接受5-ASA治療潰瘍性大腸炎八個月後，突然發生小便變少及全身水腫的情形，病人並無其他的疾病或是藥物使用；腎臟穿刺切片檢查發現膜性增生腎絲球腎炎。經停止使用5-ASA及改以類固醇及利尿劑治療三週後，目前復原良好，同時也沒有造成永久性的腎臟傷害。
關鍵字
無資料並列摘要
5-aminosalicylic acid (5-ASA) has been the standard drug to treat inflammatory bowel disease, including ulcerative colitis, for many years. However, several cases of nephrotoxicity caused by 5-ASA have been reported. We report a 29-year-old male who had received 5-ASA for ulcerative colitis for about eight months before developing oliguria and pitting edema with sudden onset. There was no other history of disease or medication use. The histopathology revealed the membranoproliferative glomerulonephritis. After stopping the use of 5-ASA and replacing treatment with prednisone for three weeks, the patient recovered well without impairment of renal function.
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