Primary Squamous Cell Carcinoma of the Prostate: Report of a Case

原發性攝護腺鱗狀上皮癌是一種少見的惡性腫瘤，約佔全部攝護腺扇0.2~0.6%。其發生的原因並非十分清楚。我們發表此疾病的臨床、生化特徵及治療方法。我們以回溯法去尋找本院從1990年11月到2007年6月患有攝護腺癌症的病患。其中，在1389位的攝護腺癌症病患中，只發現1個爲原發性攝護腺鱗狀上皮癌。這位病患年紀即1歲，其臨床症狀包括膀胱出口阻塞、血尿及解尿疼痛。經直腸超音波檢查並未顯示有低回音病兆處。攝護腺特異特原也在正常範圍內。肛門指診顯示堅實的堅硬度，雙側對稱性增大，並無明顯堅硬的腫塊。診斷經由病理切片檢驗確定。攝護腺鱗狀上皮臨床上的表現十分惡性，從確定診斷後平均存活時間約14個月。參考的文章提及根除性手術、放射治療及用mitroxantrone及cisplatin爲化學劑的化學治療，但此疾病對各種治療的反應仍不十分良好。原發性攝護腺鱗狀上皮癌相當稀少，臨床上表現十分惡性，預後亦不好，故作此報告。

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並列摘要

Primary squamous cell carcinoma of the prostate is extremely rare and accounts for0.2 to 0.6% of all the cases of prostate cancers. The etiology is unclear. There are1389 cases diagnosed as prostate cancer in our hospital from November, 1990 to June, 2007. Among these cases, only one case with squamous cell carcinoma of the prostate was encountered. The patient was 71 years old and his clinical symptoms included bladder outlet obstruction, hematuria, and dysuria. Transrectal ultrasound showed no hypoechoic lesions and the prostatic specific antigen (PSA) was normal. Digital rectal examination of the prostate revealed firm consistency, symmetric enlargement without nodularity. The diagnosis was made by needle biopsy. A review of the literature shows that primary squamous cell carcinoma of the prostate is extremely rare, and much more aggressive than adenocarcinoma of the prostate clinically with the average survival time of about 14 months after diagnosis. In various articles, radical surgery, radiotherapy and chemotherapy with mitroxantrone and cisplatin were mentioned but this kind of carcinoma responded poorly to these three modes of therapy.

並列關鍵字

squamous cell carcinoma ； prostate

國際替代計量

Primary Squamous Cell Carcinoma of the Prostate: Report of a Case

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