- 期刊
The Effect of Prostaglandin E1 on Vasoconstriction Induced By Extravasating Blood
前列腺素E1對出血性血管痙攣之效用
摘要
本計劃探討前列腺素E1對抗出血性血管痙攣之效用，利用老鼠之幾乎完全截斷之下肢(只有股動脈、股靜脈與體循環相連)接上雷射血流測定器來反應動脈痙攣之程度；實驗證實，以他隻老鼠出血之血液可造成股動脈之痙攣；實驗證實，以他隻老鼠出血之血液可造成股動脈之痙攣；但由動脈打入前列腺素E1可以預防,或迅速治療此現象之發生。由於顯微手術中出血現象不可避免，遇到皮瓣之血管莖產生痙攣影響血流時，可以由動脈打入前列腺素E1解決此問題。
關鍵字
無資料並列摘要
The hind limbs of adult rats were nearly completely amputated at mid-thigh level leaving the femoral artery and vein intact. The probe of a Laser Doppler Flowmeter was placed on the heel pad which reflected the severity of femoral vasospasm when extravasting blood from another rat was applied to the vessels. The perfusion of that limb was reduced to 40% of its original state after the clotting blood contacted the femoral vessels. This vasoconstriction effect was prevented or rapidly relieved by intra-arterial infusion of prostaglandin E1.
延伸閱讀
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