Two cases of repeated lengthening of the lower limbs by different methods are reported. Case one is a female patient diagnosed as Ollier’s disease with left femoral and tibial shortening. At age 16 years, she received her first limb lengthening for left femur and tibia using the Ilizarov external fixator device alone. Her second limb lengthening, occurring at age 22, was used both the Ilizarov external fixator and intramedullary locking nails. Case two is a male patient diagnosed as distal femoral physeal injury with left femoral shortening. He received first femoral lengthening with monolateral external fixator alone at 11 year-old. Second femoral lengthening with ilizarov external fixator along intramedullary locking nail was performed at 20 year-old. In case one, the gain in total length of the femur and tibia was 8 cm in first lengthening and 10 cm in the second. The time in the external fixator was 220 days and 56 days. The time index of external fixation was 44 days/cm and 14 days/cm. In case two, the gain in length was 5 cm in the first lengthening and 6 cm in the second. The time in the external fixator was 153 days and 81 days. The time index of external fixation was 30 days/cm and 14 days/cm. There was no major complication in these two cases. Comparing with these two methods of limb lengthening on these two patients, lengthening along intramedullary locking nail can obviously shorten the period needed in the external fixator and increase the patient’s comfort than lengthening with external fixator alone. We conclude that limb lengthening by callotasis with combined Ilizarov external fixator and intramedullary locking nail can shorten the treatment in the external fixator period, and have good results in the same patients especially in repeated limb lengthening.