We herein report the case of a 22-year-old woman who presented with a tender, enlarging, soft tissue mass and intractable lower back pain. Image studies revealed diffused bilateral multiloculated iliopsoas abscesses associated with L3~4 destruction. Surgery through a left-sided retroperitoneal approach and anti-tuberculosis medication were administered to treat the proven pathology. Owing to inadequate surgical debridement using a one-sided approach, low back pain recurred and a huge residual right iliopsoas abscess was found two months later. Instead of another extensive surgical intervention, percutaneous catheter drainage was performed to treat this sequelae, followed by 12 months of anti-tuberculosis chemotherapy. No clinical or radiological relapse occurred after 24 months of follow-up.