補充綜合抗氧化維生素增強高血脂症抽煙者之抗氧化狀態與減少血漿及低密度脂蛋白之脂質過氧化

本研究目的在於瞭解補充綜合抗氧化維生素（β-胡蘿蔔素+維生素C+維生素E）對高血脂症抽煙男性的抗氧化狀態、血漿與低密度脂蛋白中脂質過氧化、血壓與血漿脂質濃度的影響；同時評估補充劑量（15mgβ-胡蘿蔔素+500mg維生素C+400mg維生素E；補充低劑量組，或30mg-β胡蘿蔔素+1000mg維生素C+800mg維生素E；補充高劑量組）和補充時間（3或6週）之影響程度。結果顯示：高血脂症抽煙者之飲食攝取量，並不受補充劑量或補充時間的影響。然而，補充綜合抗氧化維生素三週後，高血脂症抽煙者血漿中之抗氧化維生素濃度均比實驗前明顯上升，並有持續上升的現象，於第六週時，補充低劑量組血漿中的β-胡蘿蔔素、維生素C和維生素E濃度分別比實驗前明顯上升191%、98%與130%，而補充高劑量組血漿中的β-胡蘿蔔素、維生素C和維生素E濃度則分別比實驗前明顯上升212%、216%與198%。且低、高劑量組血漿中總抗氧化狀態均顯著提升。血漿中脂質過氧化物的濃度於補充低劑量組第三週時比實驗前明顯減少16%；而補充高劑量組於第六週亦明顯降低仰17%。兩組低密度脂蛋白中脂質過氧化物的濃度也隨著抗氧化維生素補充時間的延長而下降。但綜合抗氧化維生素的補充於研究期間並不影響高血脂症抽煙者之血壓與血漿脂質濃度。因此，補充綜合抗氧化維生素六週後，高血脂症抽煙者血漿中抗氧化狀態提昇，而血漿與低密度脂蛋白中脂質過氧化物含量則降低。然而，補充低、高劑量組對於抗氧化狀態的影響程度則相似。

關鍵字

高血脂症抽煙者；抗氧化維生素；抗氧化狀態；脂質過氧化

並列摘要

The purpose of this study was to determine the effects of supplementation with combined antioxidant vitamins (β-carotene+vitamin C+vitamin E) on antioxidant status and lipid peroxidation in the plasma and in LDL, on blood pressure and on plasma lipid levels of hyperlipidemic smoking males. Furthermore, the effects of the dosage (15mg β-carotene+500mg vitamin C+400mg vitamin E or30mg β-carotene+1000mg vitamin C+800mg vitamin E) and the duration (3-or 6-week) of the supplementation were also studied. The results showed that dietary intake in hyperlipidemic smokers was affected neither by the dosage nor by the duration of the supplementation. However, the concentrations of plasma antioxidant vitamins were significantly higher in hyperlipidemic smokers after a 3-week supplementation with combined antioxidant vitamins than before supplementation. After a 6-week supplementation, plasma levels of β-carotene, vitamin C, and vitamin E were significantly increased by191, 98, and130%, respectively, in the low-dose supplementation group, and by 212, 216, and198%, respectively, in the high-dose supplementation group. Total antioxidant status in the plasma was also significantly elevated in both groups. The levels of plasma lipid peroxidation products were significantly decreased by 16% in the low-dose supplementation group after a 3-week supplementation, and by 17% in high-dose supplementation group after a 6-week supplementation. The levels of lipid peroxidation products in the LDL were reduced with increased duration of the supplementation in both groups. However, blood pressure and plasma lipid levels were not affected in hyperlipidemic smokers supplemented with combined antioxidant vitamins during the experimental period. Therefore, hyperlipidemic smokers had increased antioxidant status in the plasma, but decreased lipid peroxidation in the plasma and LDL after a 6-week supplementation with combined antioxidant vitamins. Similar effects on the antioxidant status of high and low doses of the supplementation were found.

並列關鍵字

hyperlipidemic smokers ； antioxidant vitamins ； antioxidant status ； lipid peroxidation

國際替代計量

補充綜合抗氧化維生素增強高血脂症抽煙者之抗氧化狀態與減少血漿及低密度脂蛋白之脂質過氧化

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