Peripheral Arterial Disease and Its Correlates in Chronic Hemodialysis Patients

長期血液透析病人之周邊動脈疾病及其相關因子

蔡丞凱(Cheng-Kai Tsai) ； 楊正銘(Chen-Ming Yang) ； 林勤堯(Chin-Yao Lin) ； 張宗興(Chung-Hsin Chang)

《Acta Nephrologica》 22卷2期 (2008/06) Pp. 117-123

摘要

Background: Peripheral arterial disease (PAD) is a common condition resulting from systemic atherosclerosis and often leads to substantial morbidity and mortality in patients with end stage renal disease (ESRD). Since past studies reporting on this are few, it is noteworthy to identify its prevalence and the clinical correlation between PAD and patients with maintenance hemodialysis (HD).
Methods: Two hundred and forty six patients flout a single medical center received HD for more than 3 months were screened for PAD by means of the ankle-brachial index (ABI). A ratio of＜0.9 was indicative of an abnormal ABI. We also examined lots of clinical and biochemical parameters to check their correlation with PAD.
Results: The prevalence rate of PAD (ABI＜0.9) was 243%, ABI was positively correlated with serum albumin (r=0.252, p＜0.001), serum creatinine (r=0.328, p＜0.001), serum phosphate (r=0.181, p=0.005), serum iPTH (r=0.139, p=0.030), serum calcium phosphate ate product (r=0.174, p=0.006), and serum HDL-cholesterol (r=0.189, p=0.003); and negatively correlated with age (r=0.223, P＜0.001). In univariate analysis, PAD was found to he positively associated with pre-existing cardiovascular disease (CVD), age and diabetes mellitus, but negatively associated with serum albumin and serum creatinine. Multivariate logistic regression analysis showed that PAD was associated with age, DLVI, serum creatinine and serum albumin.
Conclusion: In the present study, we found high prevalence of PAD among Taiwanese patients on chronic hemodialysis. Age, diabetes mellitus, serum creatinine and serum albumin are independent predictors of PAD.

關鍵字

周邊動脈疾病 ； 動脈硬化 ； 血液透析 ； 慢性腎臟病 ； 末期腎臟疾病

並列摘要

Background: Peripheral arterial disease (PAD) is a common condition resulting from systemic atherosclerosis and often leads to substantial morbidity and mortality in patients with end stage renal disease (ESRD). Since past studies reporting on this are few, it is noteworthy to identify its prevalence and the clinical correlation between PAD and patients with maintenance hemodialysis (HD).
Methods: Two hundred and forty six patients flout a single medical center received HD for more than 3 months were screened for PAD by means of the ankle-brachial index (ABI). A ratio of＜0.9 was indicative of an abnormal ABI. We also examined lots of clinical and biochemical parameters to check their correlation with PAD.
Results: The prevalence rate of PAD (ABI＜0.9) was 243%, ABI was positively correlated with serum albumin (r=0.252, p＜0.001), serum creatinine (r=0.328, p＜0.001), serum phosphate (r=0.181, p=0.005), serum iPTH (r=0.139, p=0.030), serum calcium phosphate ate product (r=0.174, p=0.006), and serum HDL-cholesterol (r=0.189, p=0.003); and negatively correlated with age (r=0.223, P＜0.001). In univariate analysis, PAD was found to he positively associated with pre-existing cardiovascular disease (CVD), age and diabetes mellitus, but negatively associated with serum albumin and serum creatinine. Multivariate logistic regression analysis showed that PAD was associated with age, DLVI, serum creatinine and serum albumin.
Conclusion: In the present study, we found high prevalence of PAD among Taiwanese patients on chronic hemodialysis. Age, diabetes mellitus, serum creatinine and serum albumin are independent predictors of PAD.

並列關鍵字

peripheral arterial disease ； atherosclerosis ； hemodialysis ； chronic kidney disease ； end-stage renal disease