Gordonia Sputi Bacteremia: Two Cases Report

Gordonia Sputi菌血症：2個案例之報告

黃淑鍰(Shu-Huan Huang) ； 許文騰(Wen-Teng Hsu) ； 顧凱閔(Kai-Min Ku) ； 趙少文(Shao-Wen Chao) ； 黃成正(Cheng-Cheng Hwang)

《Journal of Biomedical & Laboratory Sciences》 29卷2期 (2017/06) Pp. 60-65

摘要

Gordonia sputi is a rare but serious cause of infection in immunocompromised patients. Identification of Gordonia species can be time consuming, and these species may be dismissed as contaminating diptheroids or misidentified as other gram-positive bacilli, such as Rhodococcus or Nocardia species, when using traditional biochemical methods. Thus, it is important to consider infection by Gordonia sp. when blood culture pathogen identification is inconclusive and when the patient does not respond to empirical antimicrobial therapy. For accurate identification of G. sputi, matrix- assisted laser desorption ionization time-of-flight mass spectrometry and 16S rRNA gene sequencing are suggested.

關鍵字

Gordonia sputi ； bacteremia ； matrix-assisted laser desorption ionization time-of-flight mass spectrometry

並列摘要

Gordonia sputi是少見的細菌，於免疫功能低下病人它是細菌感染的重要原因。而鑑定G. sputi用傳統的生化方法可能會非常耗時或不準確，也可能被認為是污染菌或使用傳統的生化方法鑑定常鑑定為其他革蘭氏陽性桿菌，如Rhodococcus或Nocardia species。當血液培養病原體鑑定是不確定的，在臨床上敗血症的病人若抗生素治療一直無法好轉，而且無法鑑定出結果，我們必須考慮是Gordonia sp.引起的細菌感染，為了準確鑑定G. sputi建議可以使用基質輔助激光解吸電離-飛行時間式質譜儀(MALDI-TOF)和16S rRNA基因測序鑑定。

並列關鍵字

Gordonia sputa ； Bacteremia ； matrix-assisted laser desorption ionization time-of-flight mass spectrometry